Spectrotemporal receptive fields in the lemniscal auditory thalamus and cortex
Spectrotemporal receptive fields in the lemniscal auditory thalamus and cortex
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DOI：
10.1152/jn.00395.2001
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发表时间：
2002-01-01
影响因子：
2.5
通讯作者：
Schreiner, CE
中科院分区：
文献类型：
--
作者：
Miller, LM;Escabí, MA;Schreiner, CE
感受野在丘系听觉丘脑和皮层中具有独立的特征，通常具有针对特定任务的spectrotemporal简单声音。没有研究采用自然主义的刺激，调查丘脑皮层的时间，频谱和听觉领域的转变，同时在相同的条件下。我们同时记录在腹侧司的内侧膝状体（MGBV）和初级听觉皮层（AI）的氯胺酮麻醉的猫。单单位（n = 387）的谱时感受野（STRFs）的反向相关的宽带和动态变化的刺激，动态涟漪。通过兴奋性带宽和频谱调制偏好测量的频谱整合在两个站点之间相似（平均Q（1/e）丘脑= 5.8，皮质= 5.4;频谱调制传递函数的上限，丘脑= 1.30周期/倍频程，皮质= 1.37周期/倍频程）。从丘脑到皮质的时间调制速率减慢了两倍（平均首选速率，丘脑= 32.4 Hz，皮质= 16.6 Hz;时间调制传递函数的上限，丘脑= 62.9 Hz，皮质= 37.4 Hz）。我们发现光谱和时间整合属性之间没有相关性，这表明在每个域中的兴奋-抑制相互作用的基础偏好在很大程度上是独立的。在每个站的少数神经元有高度不对称的STRF，频率扫描选择性的证据，但人口没有显示出方向性的偏见。双耳偏好的相对比例不同，最明显的是皮质（40%）与丘脑（23%）中仅兴奋性对侧细胞的患病率增加，表明该参数的重组。通过同时比较沿着多个刺激尺寸在两个站，这些观察建立的丘脑皮层感受野转换的全球性特点。
Receptive fields have been characterized independently in the lemniscal auditory thalamus and cortex, usually with spectrotemporally simple sounds tailored to a specific task. No studies have employed naturalistic stimuli to investigate the thalamocortical transformation in temporal, spectral, and aural domains simultaneously and under identical conditions. We recorded simultaneously in the ventral division of the medial geniculate body (MGBv) and in primary auditory cortex (AI) of the ketamine-anesthetized cat. Spectrotemporal receptive fields (STRFs) of single units (n = 387) were derived by reverse-correlation with a broadband and dynamically varying stimulus, the dynamic ripple. Spectral integration, as measured by excitatory bandwidth and spectral modulation preference, was similar across both stations (mean Q(1/e) thalamus = 5.8, cortex = 5.4; upper cutoff of spectral modulation transfer function, thalamus = 1.30 cycles/octave, cortex = 1.37 cycles/octave). Temporal modulation rates slowed by a factor of two from thalamus to cortex (mean preferred rate, thalamus = 32.4 Hz, cortex = 16.6 Hz; upper cutoff of temporal modulation transfer function, thalamus = 62.9 Hz, cortex = 37.4 Hz). We found no correlation between spectral and temporal integration properties, suggesting that the excitatory-inhibitory interactions underlying preference in each domain are largely independent. A small number of neurons in each station had highly asymmetric STRFs, evidence of frequency sweep selectivity, but the population showed no directional bias. Binaural preferences differed in their relative proportions, most notably an increased prevalence of excitatory contralateral-only cells in cortex (40%) versus thalamus (23%), indicating a reorganization of this parameter. By comparing simultaneously along multiple stimulus dimensions in both stations, these observations establish the global characteristics of the thalamocortical receptive field transformation.