STAT2 phosphorylation and signaling.
STAT2 phosphorylation and signaling.
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DOI：
10.4161/jkst.25790
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发表时间：
2013-10-01
期刊：
影响因子：
--
通讯作者：
Gamero AM
中科院分区：
文献类型：
--
作者：
Steen HC;Gamero AM
STAT2是I型干扰素介导的抗病毒和抗增殖信号中必不可少的转录因子。STAT2的功能受酪氨酸磷酸化的调节，酪氨酸磷酸化是干扰素刺激基因的STAT二聚化、随后的核转位和转录激活的触发因素。有证据表明有更多的STAT2磷酸化位点，以及STAT2与经典的ISGF3信号不同的新作用。本文综述了磷酸化介导的STAT2调控的知识和未来相关STAT2研究的途径。
STAT2 is an essential transcription factor in type I IFN mediated anti-viral and anti-proliferative signaling. STAT2 function is regulated by tyrosine phosphorylation, which is the trigger for STAT-dimerization, subsequent nuclear translocation, and transcriptional activation of IFN stimulated genes. Evidence of additional STAT2 phosphorylation sites has emerged as well as novel roles for STAT2 separate from the classical ISGF3-signaling. This review aims to summarize knowledge of phosphorylation-mediated STAT2-regulation and future avenues of related STAT2 research.