Fungal Biofilms: Relevance in the Setting of Human Disease.
Fungal Biofilms: Relevance in the Setting of Human Disease.
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DOI：
10.1007/s12281-010-0035-5
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发表时间：
2010-12-01
影响因子：
1.4
通讯作者：
Fries BC
中科院分区：
文献类型：
--
作者：
Martinez LR;Fries BC
留置医疗设备的使用正在迅速增长，而且往往会因为感染了对抗菌剂和宿主防御机制具有抗药性的生物膜形成微生物而变得复杂。真菌生物被膜已成为与这些医疗器械感染相关的临床问题，导致显著的发病率和死亡率。本文综述了真菌生物膜研究的最新进展，包括真菌表面成分在生物膜形成过程中的附着、基因表达和群体感应等方面的作用。我们提出了预防或根除医疗假体微生物定植的新策略。
The use of indwelling medical devices is rapidly growing and is often complicated by infections with biofilm-forming microbes that are resistant to antimicrobial agents and host defense mechanisms. Fungal biofilms have emerged as a clinical problem associated with these medical device infections, causing significant morbidity and mortality. This review discusses the recent advances in the understanding of fungal biofilms, including the role of fungal surface components in adherence, gene expression, and quorum sensing in biofilm formation. We propose novel strategies for the prevention or eradication of microbial colonization of medical prosthetic devices.