Pd-catalyzed tandem cyclization of ethyl glyoxalate and amines: rapid assembly of highly substituted cyclic dehydro-α-amino acid derivatives.
Pd-catalyzed tandem cyclization of ethyl glyoxalate and amines: rapid assembly of highly substituted cyclic dehydro-α-amino acid derivatives.
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DOI：
10.1021/ol302483f
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发表时间：
2012-10
期刊：
影响因子：
5.2
通讯作者：
Yue Luo;Xiaoxia Lu;Yong Ye;Ya Guo;Huanfeng Jiang;W. Zeng
中科院分区：
文献类型：
--
作者：
Yue Luo;Xiaoxia Lu;Yong Ye;Ya Guo;Huanfeng Jiang;W. Zeng
在Pd（TFA）（2）（5mol%）存在下，乙醛酸乙酯与胺进行级联环化反应，得到了一系列的环状α-氨基酸衍生物。该方法提供了一种快速、简单、高产率地获得高度取代的二氢吡咯-2-酮的方法。
A novel cascade cyclization of ethyl glyoxalate and amines proceeds in the presence of Pd(TFA)(2) (5 mol %) to give the cyclic dehydro-α-amino acid derivatives. This method provides a fast and simple access to highly substituted dihydro-pyrrol-2-ones in good yields.