Copper-64 labeled sulfophthalocyanines for positron emission tomography (PET) imaging in tumor-bearing rats
Copper-64 labeled sulfophthalocyanines for positron emission tomography (PET) imaging in tumor-bearing rats
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DOI：
10.1142/s1088424608000078
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发表时间：
2008-01-01
影响因子：
1.5
通讯作者：
van Lier, Johan E.
中科院分区：
文献类型：
--
作者：
Soucy-Faulkner, Anton;Rousseau, Jacques A.;van Lier, Johan E.
磺化金属酞菁（PcS）是光动力学疗法（PDT）的第二代光敏剂。用Cu-64（++）标记无金属的H，PcS，得到磺化[Cu-64]CuPcS的混合物，适合于用正电子发射断层扫描（PET）研究荷瘤大鼠体内的生物分布。大部分Cu-64活性被隔离在肾脏（20%ID/g）和肝脏（12%ID/g）内，而肿瘤摄取值保持较低（0.2%ID/g）。在24小时扫描后对单个组织样本进行解剖和计数，确认了PET图像的摄取值。该程序可应用于一系列新的PcS，以评估结构-肿瘤选择性关系，作为选择潜在的光动力治疗药物的参数。版权所有（c）2008年卟啉和酞菁协会。
Sulfonated metal lophthaloc yanines (PcS) are second generation photosensitizers for photodynamic therapy (PDT) of cancer. Metal-free H,PcS are readily labeled with Cu-64(++) to yield a mixture of sulfonated [Cu-64]CuPcS suitable for biodistribution studies in tumor-bearing rats by positron emission tomography (PET). Most of the Cu-64 activity was sequestrated within the kidneys (20%ID/g) and liver (12%ID/g) while tumor uptake values remained low (0.2%ID/g). Dissection and counting of individual tissue samples after the 24 h scan confirmed the uptake values derived from the PET images. The procedure can be applied to series of novel PcS to evaluate structure-tumor selectivity relationships as a parameter to select potential agents for photodynamic therapy. Copyright (c) 2008 Society of Porphyrins & Phthalocyanines.