Glycaemia (haemoglobin A1c) and incident ischaemic stroke:: the atherosclerosis risk in communities (ARIC) study
Glycaemia (haemoglobin A1c) and incident ischaemic stroke:: the atherosclerosis risk in communities (ARIC) study
复制标题
DOI：
10.1016/s1474-4422(05)70227-1
复制
发表时间：
2005-12-01
期刊：
影响因子：
48
通讯作者：
Sharrett, AR
中科院分区：
文献类型：
--
作者：
Selvin, E;Coresh, J;Sharrett, AR
糖尿病患者中风的风险增加，但持续的高血糖是否有助于脑血管疾病的发展尚不清楚。血红蛋白A1 c（HbA（1c））是一种长期高血糖的指标，与糖尿病视网膜病变、肾病和神经病变密切相关。我们试图评估糖化血红蛋白（1c）和中风的人，没有糖尿病和糖尿病的ARIC研究，谁没有心血管疾病的10 886名参与者和1635名参与者之间的关联，随访缺血性中风事件超过8-10年。我们检测了所有167例中风病例和680例非糖尿病成人样本以及1635例糖尿病成人（包括89例中风病例）的HbA（1c）。我们使用考克斯比例风险模型评估了随访期间HbA 1c浓度（糖尿病和非糖尿病个体的三分位数）和缺血性卒中事件之间的关系，控制了卒中的危险因素。
Background Individuals with diabetes have a raised risk of stroke, but it is unclear whether sustained hyperglycaemia contributes to the development of cerebrovascular disease. Haemoglobin A1c (HbA(1c)), a measure of long-term glycaemia, is strongly related to retinopathy, nephropathy, and neuropathy in diabetes. We sought to assess the association between HbA(1c) and stroke in people with and without diabetes.Methods 10 886 participants without diabetes and 1635 participants with diabetes in the ARIC study, who did not have cardiovascular disease, were followed up for incident ischaemic stroke over 8-10 years. We assayed HbA(1c) for all 167 stroke cases and a sample of 680 non-cases in the adults without diabetes and for the full cohort of 1635 adults with diabetes (including 89 stroke cases). We assessed the relation between HbA(1c) concentrations (in tertiles specific for individuals with and without diabetes) and incident ischaemic stroke during follow-up using Cox proportional hazards models, controlling for risk factors for stroke.Findings The adjusted relative risks of stroke increased with increasing tertile of HbA1c in both adults without diabetes (p=0.02) and with diabetes (p