Serum levels of Thl/Th2 cytokines, angiogenic growth factors, and other prognostic factors in young adult patients with hemophagocytic syndrome.
Serum levels of Thl/Th2 cytokines, angiogenic growth factors, and other prognostic factors in young adult patients with hemophagocytic syndrome.
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DOI：
10.1532/lh96.05035
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
Bessho, Masami
中科院分区：
文献类型：
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作者：
Murohashi, Ikuo;Yoshida, Katsuhiko;Bessho, Masami
本文测定了5例年轻成年病毒相关性噬血细胞综合征（HPS）患者血清T辅助1 (Th1)/T辅助2 （Th2）细胞因子、血管生成生长因子及其他预后因素的水平。2 - Th1细胞因子（白细胞介素[IL]-18和肿瘤坏死因子- α）、2 - Th2细胞因子（IL-10和IL-6）和2 -血管生成生长因子（可溶性细胞间粘附分子-1和肝细胞生长因子）的水平在所有被检查的患者中均较高，而Th1细胞因子如IL-12和巨噬细胞炎症蛋白-1a的水平正常或较低。病例2中IL-18和IL-10水平最高，导致死亡；病例4中IL-18和IL-10水平最低，1个月内迅速恢复。虽然2例患者（病例3和5）的ifn - γ水平未升高，但这2例患者的IL-18水平均显著升高，而病例3的IL-6水平最高。病例3与IL-10水平明显升高相反，IL-6、sIL-2R、铁蛋白水平迅速下降，治疗后2个月内恢复正常。IL-18水平有所下降，但在6个月内保持升高，患者在11个月内达到完全缓解。综上所述，我们的研究结果表明，IL-18和IL-10，而不是IL-12，可能分别通过增强和抑制Th1免疫应答在年轻成年HPS患者中发挥重要作用。
Serum levels of T helper 1 (Th1)/T helper 2 (Th2) cytokines, angiogenic growth factors, and other prognostic factors were measured in 5 young adult patients with virus-associated hemophagocytic syndrome (HPS). Levels of 2 Th1 cytokines (interleukin [IL]-18 and tumor necrosis factor-alpha), 2 Th2 cytokines (IL-10 and IL-6), and 2 angiogenic growth factors (soluble intercellular adhesion molecule-1 and hepatocyte growth factor) were high in all of the patients examined, whereas those of Th1 cytokines such as IL-12 and macrophage inflammatory protein-1a were normal or low. Levels of IL-18 and IL-10 were highest in case 2, with a fatal outcome, and were lowest in case 4, with rapid recovery within 1 month. Although IFN-gamma levels were not elevated in 2 patients (cases 3 and 5), IL-18 levels were markedly high in both of these cases and the IL-6 level was highest in case 3. In contrast with the marked increase in the level of IL-10, the levels of IL-6, sIL-2R, and ferritin decreased rapidly and returned to normal within 2 months after therapy in case 3. The IL-18 level decreased somewhat, but remained elevated for 6 months, and the patient achieved a complete response within 11 months. Taken together, our findings suggest that both IL-18 and IL-10, but not IL-12, may play important roles in young adult patients with HPS via enhancing and suppressing Th1 immune responses, respectively.