A case of meningitis due to extensively drug-resistant Pseudomonas aeruginosa imported through medical evacuation: Genomic and environmental investigation
A case of meningitis due to extensively drug-resistant Pseudomonas aeruginosa imported through medical evacuation: Genomic and environmental investigation
复制标题
医疗后送输入的广泛耐药铜绿假单胞菌所致脑膜炎一例：基因组和环境调查
DOI：
10.1093/jtm/taab047
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发表时间：
2021
影响因子：
25.7
通讯作者：
Koichi Tokuda
中科院分区：
文献类型：
--
作者：
Hiroaki Baba;Hajime Kanamori;Makoto Katsumi;Takami Sato;Takae Chida;Shinobu Ikeda;Yuki Suzuki;Hisakazu Yano;Koichi Tokuda
国际旅行在抗菌素耐药性（AMR）的全球传播中起着重要作用。1前往流行地区的旅行者返回原籍国时，往往带有耐多药微生物，并可将其带入家庭、社区和卫生保健设施。日本越来越多地报告了从西南亚国家输入的MDROs暴发。3由于MDROs非常昂贵，一旦获得就难以控制，因此对具有各自旅行史的患者进行MDROs定植的风险评估和基于原籍国和目的地国流行病学的控制措施对于防止患者住院后MDROs进一步传播至关重要。我们经历了一例通过医疗后送（医疗后送）输入到日本一所大学医院的广泛耐药铜绿假单胞菌（XDRPA）引起的神经外科术后脑膜炎病例。患者3年前在东南亚某国接受开颅手术，当时可能感染了XDR-PA。我们通过全基因组测序（WGS）检查了患者的XDR-PA定植和患者房间的环境污染。
International travel plays a major role in the global spread of antimicrobial resistance (AMR). 1 Travellers to endemic areas return to their home country frequently colonized with multidrug-resistant organisms (MDROs) and can introduce them into their households, communities and healthcare facilities. 2 Outbreaks of MDROs imported from Southwest Asian countries have increasingly been reported in Japan. 3 Because MDROs are extremely expensive and difficult to control once acquired, risk assessments of MDROs colonization in patients with respective travel histories and control measures based on the epidemiology of both the home and destination countries are crucial to prevent further spread of MDROs if the patients are admitted to hospital. 1We experienced a case of post-neurosurgical meningitis due to extensively drug-resistant Pseudomonas aeruginosa (XDRPA) imported through medical evacuation (medevac) to a university hospital in Japan. The patient underwent craniotomy in a Southeast Asian country 3 years ago and presumably acquired XDR-PA at that time. We examined the XDR-PA colonization of the patient and the environmental contamination of the patient’s room by whole-genome sequencing (WGS)