Sex-linked ultrastructural dichotomy of gonadotroph adenomas of the human pituitary: an electron microscopic analysis of 145 tumors.
Sex-linked ultrastructural dichotomy of gonadotroph adenomas of the human pituitary: an electron microscopic analysis of 145 tumors.
复制标题
人类垂体促性腺激素腺瘤的性别连锁超微结构二分法：145 个肿瘤的电子显微镜分析。
作者：
G. Kontogeorgos;É. Horváth;K. Kovacs
本文观察了145例垂体促性腺激素腺瘤的超微结构，特别是高尔基体的精细结构。其中85个肿瘤是从男性身上切除的，60个是从女性身上切除的。除少数男性外，促性腺激素过度分泌在临床上并未得到证实，诊断仅基于形态学基础。由于性别相关的二型性，男性和女性肿瘤的诊断标准不同。在男性中，大约50%的腺瘤结构分化良好，而其余的肿瘤由显示不同程度分化的区域组成。在男性的任何肿瘤中，高尔基复合体都没有显示出空泡转化的迹象。在女性中，超过70%的肿瘤均分化良好，表现为高尔基复合体(蜂窝高尔基复合体)的囊泡状转化，这是一种特征性的诊断标记。在两个腺瘤中，不是蜂窝状高尔基复合体，而是高尔基体的另一种独特的改变，包括高尔基复合体转变为底部有一对中心粒的三分体三叶状结构。这种不寻常的变化可能是蜂窝高尔基复合体的先导。高尔基复合体的差异被认为是性腺激素调节和功能在两性中不同的形态表现。
The ultrastructure of 145 pituitary gonadotroph adenomas was investigated with special regard to the fine structural appearance of the Golgi apparatus. Eight-five of the tumors were removed from men, 60 from women. Except for a few males, gonadotropin oversecretion was not established clinically and the diagnosis had been made solely on morphologic grounds. Owing to sex-related dimorphism, the diagnostic criteria were different for tumors of men and women. In men, approximately 50% of adenomas were structurally well-differentiated, whereas the rest of the tumors consisted of areas showing varying degrees of differentiation. The Golgi complex exhibited no signs of vacuolar transformation in any of the tumors in men. In women, more than 70% of tumors were uniformly well-differentiated, displaying vesicular transformation of Golgi complex (honeycomb Golgi complex), a characteristic diagnostic marker. In two adenomas, instead of the honeycomb Golgi complex, another unique alteration of the Golgi apparatus was encountered, comprising transformation of Golgi complex into a tripartite cloverleaflike structure with a pair of centrioles at its base. As suggested by formation of vacuoles in the center of the loops, this unusual change may be the fore-runner of honeycomb Golgi complex. Differences of the Golgi complex are viewed as morphologic expression of the fact that gonadotroph regulation and function in the two sexes are not the same.