BLADDER-CANCER AND OCCUPATIONAL EXPOSURE TO POLYCYCLIC AROMATIC-HYDROCARBONS
BLADDER-CANCER AND OCCUPATIONAL EXPOSURE TO POLYCYCLIC AROMATIC-HYDROCARBONS
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DOI：
10.1002/ijc.2910440415
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发表时间：
1989-10-15
影响因子：
6.4
通讯作者：
PUNTONI, R
中科院分区：
文献类型：
--
作者：
BONASSI, S;MERLO, F;PUNTONI, R
在意大利Bormida山谷开展的一项基于人群的病例对照研究中，调查了职业暴露于多环芳烃（PAH）与膀胱癌发展之间的关系。121例男性病例和342例男性对照，按年龄匹配，从当地医院收集。职业暴露于多环芳烃和芳香胺（AA）的评估通过工作暴露矩阵，专门为本研究构建。被认为“明确暴露于多环芳烃”的受试者即使在吸烟和暴露于AA后也显示出增加的风险（OR = 2.14, 95% CL 0.82-5.60）。“可能暴露于多环芳烃”类别未发现风险升高（OR = 1.05, 95% CL 0.45-2.44）。本研究的结果与先前的研究一致，表明多环芳烃是膀胱癌的危险因素。讨论了AA杂质可能产生的残留混淆效应。
The association between occupational exposure to polycyclic aromatic hydrocarbons (PAH) and bladder cancer development was investigated in a population-based case-control study carried out in the Bormida valley, Italy. One hundred and twenty-one male cases and 342 male controls, matched by age, were collected from local hospitals. Occupational exposure to PAH and aromatic amines (AA) was evaluated by means of a job exposure matrix, constructed specifically for this study. Subjects considered as sharing a "definite exposure to PAH" showed an increased risk even after adjustment for cigarette smoking and exposure to AA (OR = 2.14, 95% CL 0.82-5.60). No elevation in risk was found for the category "possible exposure to PAH" (OR = 1.05, 95% CL 0.45-2.44). The findings of this study are consistent with previous studies indicating PAH as a risk factor for bladder cancer. A possible residual confounding effect due to AA impurities is discussed.