Measured and estimated glomerular filtration rate: current status and future directions
Measured and estimated glomerular filtration rate: current status and future directions
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DOI：
10.1038/s41581-019-0191-y
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发表时间：
2020-01-01
影响因子：
41.5
通讯作者：
Inker, Lesley A.
中科院分区：
文献类型：
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作者：
Levey, Andrew S.;Coresh, Josef;Inker, Lesley A.
肾小球滤过率(GFR)的评估在医学实践、研究和公共卫生中是评估肾功能的核心。测量的肾小球滤过率(MGFR)仍然是参考标准，但在过去20年中，估计的肾小球滤过率(EGFR)取得了重大进展。与真实GFR相比，EGFR和mGFR都与误差有关。EGFR现在被临床实践指南、监管机构和公共卫生机构推荐用于GFR的初步评估，测量的GFR(MGFR)通常被认为是一种重要的验证性测试，这取决于GFR评估在临床、研究或公共卫生环境中的应用需要有多准确。我们的方法是根据需要使用初始和验证性测试来开发对真实GFR的最终评估。我们建议，通过更全面地实施当前的建议，并通过进一步的研究来提高mGFR和EGFR的准确性，可以改善GFR的评估。
Evaluation of glomerular filtration rate (GFR) is central to the assessment of kidney function in medical practice, research and public health. Measured GFR (mGFR) remains the reference standard, but the past 20 years have seen major advances in estimated GFR (eGFR). Both eGFR and mGFR are associated with error compared with true GFR. eGFR is now recommended by clinical practice guidelines, regulatory agencies and public health agencies for the initial evaluation of GFR, with measured GFR (mGFR) typically considered an important confirmatory test, depending on how accurate the assessment of GFR needs to be for application to the clinical, research or public health setting. Our approach is to use initial and confirmatory tests as needed to develop a final assessment of true GFR. We suggest that GFR evaluation might be improved by more complete implementation of current recommendations and by further research to improve the accuracy of mGFR and eGFR.