FUNCTIONAL MAGNETIC-RESONANCE-IMAGING OF SOMATOSENSORY STIMULATION
FUNCTIONAL MAGNETIC-RESONANCE-IMAGING OF SOMATOSENSORY STIMULATION
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DOI：
10.1227/00006123-199410000-00014
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发表时间：
1994-10-01
期刊：
影响因子：
4.8
通讯作者：
BINDER, JR
中科院分区：
文献类型：
--
作者：
HAMMEKE, TA;YETKIN, FZ;BINDER, JR
功能磁共振成像（FMRI）已检测到局部脑血流量和体积的变化，以响应运动，视觉刺激和听觉刺激，在各自的初级皮质。本实验的目的是确定触觉刺激是否会引起躯体感觉皮层的信号变化。在受试者使用配备局部梯度和射频线圈的1.5 T磁共振扫描仪进行回波平面成像时，定期刺激右手手掌。选择10- 15-mm层厚的头颅和冠状位图像，以包括中央后回和周围区域。在6名受试者中，每名受试者的rolandic周围区域发生了1%至5%的时间相关信号变化。信号变化的时间过程与其他初级感觉和运动皮层中发现的信号变化相当。这些结果提供了初步证据的敏感性，功能磁共振成像激活的躯体感觉皮层与触觉刺激和支持功能磁共振成像作为一个有前途的非侵入性技术研究的功能组织和完整性的大脑。
FUNCTIONAL MAGNETIC RESONANCE imaging (FMRI) has detected changes in regional cerebral blood flow and volume in response to motor movements, visual stimuli, and auditory stimuli in each of their respective primary cortices. This experiment was conducted to determine whether signal changes in the somatosensory cortex secondary to tactile stimulation could be demonstrated. The palm of the right hand was periodically stimulated while the subject was undergoing echo-planar imaging with a 1.5-T magnetic resonance scanner equipped with local gradient and radio frequency coils. Sagittal and coronal images of 10- to 15-mm slice thickness were selected to include the postcentral gyrus and surrounding regions. Temporally correlated signal changes of 1% to 5% occurred in the peri-rolandic region in each of six subjects. The time course of signal changes was comparable to that found in other primary sensory and motor cortices. The results provide preliminary evidence of the sensitivity of FMRI to activation of the somatosensory cortex with tactile stimulation and support FMRI as a promising noninvasive technique for study of the functional organization and integrity of the cerebrum.