Slx4 scaffolding in homologous recombination and checkpoint control: lessons from yeast.
Slx4 scaffolding in homologous recombination and checkpoint control: lessons from yeast.
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DOI：
10.1007/s00412-016-0600-y
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发表时间：
2017-02
期刊：
影响因子：
1.6
通讯作者：
Smolka MB
中科院分区：
文献类型：
--
作者：
Cussiol JR;Dibitetto D;Pellicioli A;Smolka MB
Homologous recombination-mediated DNA repair is essential for maintaining genome integrity. It is a multi-step process that involves resection of DNA ends, strand invasion, DNA synthesis and/or DNA end ligation and, finally, the processing of recombination intermediates such as Holliday junctions or other joint molecules. Over the last 15 years, it has been established that the Slx4 protein plays key roles in the processing of recombination intermediates, functioning as a scaffold to coordinate the action of structure-specific endonucleases. Recent work in budding yeast has uncovered unexpected roles for Slx4 in the initial step of DNA-end resection and in the modulation of DNA damage checkpoint signaling. Here we review these latest findings and discuss the emerging role of yeast Slx4 as an important coordinator of DNA damage signaling responses and a regulator of multiple steps in homologous recombination-mediated repair.
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SLX1和MUS81-EME1核酸酶对Holliday连接分辨率和DNA修复的合作控制。
影响因子：
16
作者：
Castor, Dennis;Nair, Nidhi;Declais, Anne-Cecile;Lachaud, Christophe;Toth, Rachel;Macartney, Thomas J.;Lilley, David M. J.;Arthur, J. Simon C.;Rouse, John
通讯作者：
Rouse, John
DOI：
10.1073/pnas.1503331112
发表时间：
2015-04-14
影响因子：
11.1
作者：
Chen, Huan;Donnianni, Roberto A.;Symington, Lorraine S.
通讯作者：
Symington, Lorraine S.
DOI：
10.1126/science.1230624
发表时间：
2013-02-08
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Di Virgilio M;Callen E;Yamane A;Zhang W;Jankovic M;Gitlin AD;Feldhahn N;Resch W;Oliveira TY;Chait BT;Nussenzweig A;Casellas R;Robbiani DF;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
3.3
作者：
Coulon, S;Gaillard, PHL;Russell, P
通讯作者：
Russell, P
影响因子：
7.7
作者：
Bonetti, Diego;Villa, Matteo;Longhese, Maria Pia
通讯作者：
Longhese, Maria Pia