Chicken Dapper Genes Are Versatile Markers for Mesodermal Tissues, Embryonic Muscle Stem Cells, Neural Crest Cells, and Neurogenic Placodes
Chicken Dapper Genes Are Versatile Markers for Mesodermal Tissues, Embryonic Muscle Stem Cells, Neural Crest Cells, and Neurogenic Placodes
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DOI：
10.1002/dvdy.21950
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发表时间：
2009-05-01
影响因子：
2.5
通讯作者：
Dietrich, Susanne
中科院分区：
文献类型：
--
作者：
Alvares, Lucia Elvira;Winterbottom, Farrah Leigh;Dietrich, Susanne
Dapper（Dpr）蛋白是Wnt和TGF β信号传导的环境依赖性调节剂。然而，尽管已经对其分子特性进行了研究，但其表达和生物学功能尚不清楚。通过对禽类Dpr基因的研究，发现鸡只含有一个Dpr 1和一个Dpr 2基因。这些基因在原肠胚形成、神经胚形成和器官发生发育阶段以不同的模式表达，关键的表达域是后原条、前节和脊索、有丝分裂前中胚层（节段板）、外侧和心脏中胚层、肢体间充质和神经原基板，以及前原条、结节、上皮体节、胚胎肌肉干细胞、口腔外胚层和内胚层，神经嵴细胞、肢体外胚层和肺芽中的Dpr 2。在少数组织中表达重叠;然而，在几种组织中，表达是互补的。Developmental Dynamics 238：1166-1178，2009. (C)2009 Wiley-Liss，Inc.
Dapper (Dpr) proteins are context-dependent regulators of Wnt and Tgf beta signaling. However, although inroads into their molecular properties have been made, their expression and biological function are not understood. Searching for avian Dpr genes, we found that the chicken harbors a Dpr1 and a Dpr2 paralogue only. The genes are expressed in distinct patterns at gastrulation, neurulation, and organogenesis stages of development with key expression domains being the posterior primitive streak, anterior node and notochord, presomitic mesoderm (segmental plate), lateral and cardiac mesoderm, limb mesenchyme, and neurogenic placodes for Dpr1, and anterior primitive streak, node, epithelial somites, embryonic muscle stem cells, oral ectoderm and endoderm, neural crest cells, limb ectoderm, and lung buds for Dpr2. Expression overlaps in a few tissues; however, in several tissues, expression is complementary. Developmental Dynamics 238:1166-1178, 2009. (C) 2009 Wiley-Liss, Inc.