Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression.
Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression.
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DOI：
10.1155/2016/3162743
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发表时间：
2016
影响因子：
4.3
通讯作者：
Luz-Crawford P
中科院分区：
文献类型：
--
作者：
Contreras RA;Figueroa FE;Djouad F;Luz-Crawford P
间充质干细胞（MSC）是多能干细胞，其能够免疫调节来自先天免疫系统和适应性免疫系统的细胞，从而促进抗炎环境。在过去的十年中，MSC在体外和体内的自身免疫性和炎症性疾病的实验动物模型中得到了广泛的研究。基于这些研究，MSC目前被广泛用于治疗自身免疫性疾病，例如以免疫系统的复杂失调为特征的类风湿性关节炎（RA）。然而，骨髓间充质干细胞在关节炎中的治疗特性仍然存在争议。这些争议可能是由于MSC来源和分离方案的多样性，MSC给药的时间，途径和剂量，MSC抑制作用的多种机制以及关节炎发病机制的复杂性。在这篇综述中，我们讨论了骨髓间充质干细胞和与关节炎发病机制相关的不同免疫细胞之间的相互作用的作用，以及文献中描述的可能的手段，可以增强骨髓间充质干细胞的治疗潜力，对抗关节炎的发展和进展。
Mesenchymal stem cells (MSCs) are multipotent stem cells that are able to immunomodulate cells from both the innate and the adaptive immune systems promoting an anti-inflammatory environment. During the last decade, MSCs have been intensively studied in vitro and in vivo in experimental animal model of autoimmune and inflammatory disorders. Based on these studies, MSCs are currently widely used for the treatment of autoimmune diseases such as rheumatoid arthritis (RA) characterized by complex deregulation of the immune systems. However, the therapeutic properties of MSCs in arthritis are still controverted. These controversies might be due to the diversity of MSC sources and isolation protocols used, the time, the route and dose of MSC administration, the variety of the mechanisms involved in the MSCs suppressive effects, and the complexity of arthritis pathogenesis. In this review, we discuss the role of the interactions between MSCs and the different immune cells associated with arthritis pathogenesis and the possible means described in the literature that could enhance MSCs therapeutic potential counteracting arthritis development and progression.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
5.4
作者：
Duffy, Michelle M.;Pindjakova, Jana;Griffin, Matthew D.
通讯作者：
Griffin, Matthew D.
影响因子：
5.4
作者：
Dorronsoro, Akaitz;Ferrin, Izaskun;Trigueros, Cesar
通讯作者：
Trigueros, Cesar
影响因子：
5.2
作者：
Djouad, Farida;Charbonnier, Louis-Marie;Noel, Daniele
通讯作者：
Noel, Daniele