Age-dependent changes in the excretion of urinary proteins by the rat.
Age-dependent changes in the excretion of urinary proteins by the rat.
复制标题
大鼠尿蛋白排泄的年龄依赖性变化。
作者：
O. Neuhaus;W. Flory
总尿蛋白（TUP）的排泄大鼠开始在断奶和延长到12个月的年龄与输出的性别依赖性α 2u-球蛋白和白蛋白。在40日龄的青春期，TUP的排泄量与α 2u-球蛋白的输出量相对应。在这个年龄段，α 2u占总量的30%，而白蛋白不到10%。从100 ~ 200日龄，TUP保持恒定，而白蛋白排泄量稳步增加。150--180日龄以后，TUP中α_2u和白蛋白浓度基本相等。此后，白蛋白和TUP的排泄显著增加，而α 2u排泄保持恒定。在373日龄时，白蛋白占TUP的50- 60%，而α 2u仅占6- 7%。在第一年，分泌很少或没有α 2u的雌性大鼠表现出比雄性大鼠低得多的蛋白尿水平。我们建议存在两个阶段的蛋白尿的雄性大鼠，即，早期生理或α 2U-球蛋白尿阶段和后期白蛋白尿阶段，在此期间，血浆蛋白，特别是白蛋白的数量增加，丢失。
The excretion of total urinary proteins (TUP) of rats beginning at weaning and extending to 12 months of age was correlated with the output of the sex-dependent alpha2u-globulin and albumin. At puberty, 40 days of age, the excretion of TUP corresponded to the output of alpha2u-globulin. At this age, alpha2u represented 30% of the total while albumin less than 10%. From 100 to 200 days of age, TUP remained constant while the excretion of albumin steadily increased. After 150--180 days of age, the concentrations of alpha2u and albumin in TUP were approximately equal. Thereafter, the excretion of albumin and TUP increased markedly whereas alpha2u excretion remained constant. At 373 days of age, albumin represented over 50--60% of the TUP while alpha2u was only 6--7%. Female rats which excrete little or no alpha2u exhibited a much lower level of proteinuria than the male during the first year. We suggest the existence of two phases of proteinuria in the male rat, namely, an early physiologic or alpha2u-globulinuric phase and a later albuminuric phase during which increasing quantities of plasma proteins, especially albumin, are lost.