CIDEC: A Potential Factor in Diabetic Vascular Inflammation
CIDEC: A Potential Factor in Diabetic Vascular Inflammation
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CIDEC：糖尿病血管炎症的潜在因素
DOI：
10.1159/000520685
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发表时间：
2022
影响因子：
1.7
通讯作者：
Yun Ti
中科院分区：
文献类型：
--
作者：
Fang-Qiang Song;Hui-Min Zhou;Wei-Xuan Ma;Yu-Lin Li;Bo-Ang Hu;Yuan-Yuan Shang;Zhi-Hao Wang;Ming Zhong;Wei Zhang;Yun Ti
细胞死亡诱导的DFF45样效应子C(CIDEC)参与了饮食诱导的脂肪炎症。CIDEC是否在糖尿病血管炎症中起作用尚不清楚。采用高脂饮食加小剂量链脲佐菌素建立2型糖尿病大鼠模型。通过代谢试验、免疫印迹分析CIDEC和C1q/肿瘤坏死因子相关蛋白-3(CTRP3)的表达，以及对主动脉组织进行组织病理学分析，评价其特性。糖尿病组表现为CIDEC表达升高、主动脉炎症和重塑。为了进一步研究CIDEC在主动脉炎症发病机制中的作用，采用了基因沉默的方法。CIDEC基因沉默后，CTRP3的表达恢复，同时糖尿病大鼠的胰岛素抵抗、主动脉炎症和重塑得到改善。因此，CIDEC的沉默有效地介导了主动脉炎症和重塑的逆转，提示CIDEC可能是糖尿病血管并发症的潜在治疗靶点。
Cell death-inducing DFF45-like effector C (CIDEC) is involved in diet-induced adipose inflammation. Whether CIDEC plays a role in diabetic vascular inflammation remains unclear. A type 2 diabetic rat model was induced by high-fat diet and low-dose streptozotocin. We evaluated its characteristics by metabolic tests, Western blot analysis of CIDEC and C1q/tumor necrosis factor-related protein-3 (CTRP3) expression, and histopathological analysis of aortic tissues. The diabetic group exhibited elevated CIDEC expression, aortic inflammation, and remodeling. To further investigate the role of CIDEC in the pathogenesis of aortic inflammation, gene silencing was used. With CIDEC gene silencing, CTRP3 expression was restored, accompanied with amelioration of insulin resistance, aortic inflammation, and remodeling in diabetic rats. Thus, the silencing of CIDEC is potent in mediating the reversal of aortic inflammation and remodeling, indicating that CIDEC may be a potential therapeutic target for vascular complications in diabetes.