Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study.
Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study.
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DOI：
10.1016/j.ahj.2009.05.010
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发表时间：
2009-07
影响因子：
4.8
通讯作者：
Folsom, Aaron R.
中科院分区：
文献类型：
--
作者：
Alonso, Alvaro;Agarwal, Sunil K.;Soliman, Elsayed Z.;Ambrose, Marietta;Chamberlain, Alanna M.;Prineas, Ronald J.;Folsom, Aaron R.
目的：确定白人和非裔美国人群体中房颤(AF)的发生率和累积风险。据报道，非洲裔美国人比白人患房颤的风险更低，尽管他们暴露在房颤危险因素中的风险更高。然而，对非裔美国人房颤发病率的准确估计以前没有发表过。我们在社区动脉粥样硬化风险研究中研究了房颤的发病率，该研究自1987年以来对美国四个社区的15,792名年龄在45-65岁之间的男性和女性进行了跟踪调查。房颤病例是从基线和三次随访时进行的心电图以及截至2004年底的住院和死亡证明中确定的。在随访期间，发现了1085例新的房颤病例(非裔美国人196例，白人889例)。白人男性、白人女性、非裔美国人男性和非洲裔美国女性的房颤粗发病率分别为6.7、4.0、3.9和3.0/1000人/年。年龄的增长与房颤风险的增加呈指数关系。与白人相比，非洲裔美国人被诊断为房颤的年龄和性别调整风险较低41%(95%可信区间：8%-62%)。在80岁时，白人男性患房颤的累积风险为21%，白人女性为17%，非裔美国人男性和女性为11%。在这个以人群为基础的队列中，非裔美国人比白人患房颤的风险更低。尽管如此，房颤在前者中的负担是巨大的，每9人中就有1人在80岁之前被诊断为房颤。
To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African-Americans. African-Americans reportedly have a lower risk of AF than whites despite their higher exposure to AF risk factors. However, precise estimates of AF incidence in African-Americans have not been previously published. We studied the incidence of AF in the Atherosclerosis Risk in Communities Study, which has followed up 15,792 men and women aged 45-65 at baseline from four communities in the United States since 1987. AF cases were identified from ECGs conducted at baseline and three follow-up visits, and from hospitalizations and death certificates through the end of 2004. During follow-up, 1,085 new cases of AF were identified (196 in African-Americans, 889 in whites). Crude incidence rates of AF were 6.7, 4.0, 3.9 and 3.0 per 1,000 persons per year in white men, white women, African-American men and African-American women, respectively. Increasing age was exponentially associated with an elevated risk of AF. Compared to whites, African-Americans had a 41% (95% confidence interval: 8%-62%) lower age- and sex-adjusted risk of being diagnosed with AF. The cumulative risk of AF at age 80 was 21% in white men, 17% in white women, and 11% in African-American men and women. In this population-based cohort, African-Americans presented a lower risk of AF than whites. Still, the burden of AF among the former is substantial, with 1 in 9 receiving a diagnosis of AF before the age of 80.
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影响因子：
--
作者：
Glazer, Nicole L.;Dublin, Sascha;Heckbert, Susan R.
通讯作者：
Heckbert, Susan R.
影响因子：
8.3
作者：
Soliman EZ;Prineas RJ;Case LD;Zhang ZM;Goff DC Jr
通讯作者：
Goff DC Jr
影响因子：
2.8
作者：
Khairallah, F;Ezzedine, R;Saba, S
通讯作者：
Saba, S
影响因子：
6.2
作者：
McDonald, Alden J.;Pelletier, Andrea J.;Carnargo, Carlos A., Jr.
通讯作者：
Carnargo, Carlos A., Jr.
影响因子：
120.7
作者：
BENJAMIN, EJ;LEVY, D;WOLF, PA
通讯作者：
WOLF, PA