Real-time EEG-defined excitability states determine efficacy of TMS-induced plasticity in human motor cortex
Real-time EEG-defined excitability states determine efficacy of TMS-induced plasticity in human motor cortex
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DOI：
10.1016/j.brs.2017.11.016
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发表时间：
2018-03-01
影响因子：
7.7
通讯作者：
Ziemann, Ulf
中科院分区：
文献类型：
--
作者：
Zrenner, Christoph;Desideri, Debora;Ziemann, Ulf
背景：振荡神经网络中快速变化的兴奋性状态可以解释对外部刺激的反应变异性，但如果始终相同的高或低兴奋性状态的重复刺激导致相反方向的长期可塑性，则尚未在体内进行探索。 目的/假设：内源性感觉运动 m 节律的不同阶段代表皮质脊髓兴奋性的不同状态，并且重复的经颅磁 始终相同的高刺激（rTMS）与低刺激（rTMS）低兴奋性状态导致不同方向的长期可塑性。方法：使用状态依赖性脑电图触发经颅磁刺激（EEG-TMS），使用毫秒分辨率实时数字信号处理系统，针对健康受试者的感觉运动 mu 节律的 EEG 负峰值与正峰值。皮质脊髓兴奋性由手部肌肉中的运动诱发电位振幅来索引。结果：内源性感觉运动 m 节律的 EEG 负峰与正峰分别代表高峰与高峰。皮质脊髓神经元的低兴奋状态。更重要的是，在这种高兴奋性与低兴奋性状态下一致触发的相同 rTMS（100 Hz 突发频率下的 200 个三脉冲，类似于 1 Hz 重复率）会导致皮质脊髓兴奋性的类似长时程增强 (LTP) 变化与无变化。结论：研究结果提出了一种有趣的可能性，即可以利用瞬时大脑状态的实时信息 控制人类可塑性诱导的功效。 (C) 2017 Elsevier Inc. 保留所有权利。
Background: Rapidly changing excitability states in an oscillating neuronal network can explain response variability to external stimulation, but if repetitive stimulation of always the same high-or low-excitability state results in long-term plasticity of opposite direction has never been explored in vivo.Objective/hypothesis: Different phases of the endogenous sensorimotor m-rhythm represent different states of corticospinal excitability, and repetitive transcranial magnetic stimulation (rTMS) of always the same high-vs. low-excitability state results in long-term plasticity of different direction.Methods: State-dependent electroencephalography-triggered transcranial magnetic stimulation (EEG-TMS) was applied to target the EEG negative vs. positive peak of the sensorimotor mu-rhythm in healthy subjects using a millisecond resolution real-time digital signal processing system. Corticospinal excitability was indexed by motor evoked potential amplitude in a hand muscle.Results: EEG negative vs. positive peak of the endogenous sensorimotor m-rhythm represent high-vs. low-excitability states of corticospinal neurons. More importantly, otherwise identical rTMS (200 triple-pulses at 100 Hz burst frequency and similar to 1 Hz repetition rate), triggered consistently at this high-excitability vs. low-excitability state, leads to long-term potentiation (LTP)-like vs. no change in corticospinal excitability.Conclusions: Findings raise the intriguing possibility that real-time information of instantaneous brain state can be utilized to control efficacy of plasticity induction in humans. (C) 2017 Elsevier Inc. All rights reserved.