Phosphine-Catalyzed Enantioselective [4 2] Annulation of o-Quinone Methides with Allene Ketones
Phosphine-Catalyzed Enantioselective [4 2] Annulation of o-Quinone Methides with Allene Ketones
复制标题
膦催化的对映选择性 [4 2] 邻醌甲基化物与联烯酮的环化
DOI：
10.1021/acs.orglett.7b01936
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Lu Yixin
中科院分区：
文献类型：
--
作者：
Wang Zhen;Wang Tianli;Yao Weijun;Lu Yixin
本文报道了膦催化的邻醌甲基化物与联烯酮的[4 + 2]成环反应。报道的方法导致的苯并二氢吡喃衍生物的形成在高产率和良好的对映选择性。这是首次将邻醌甲基化物用于膦介导的环化反应。
A phosphine-catalyzed highly enantioselective [4 + 2] annulation betweenortho-quinone methides and allene ketones has been developed. The reported method led to the formation of chromane derivatives in high yields and excellent enantioselectivity. This is the first time thatortho-quinone methides are employed in phosphine-mediated cyclization reactions.