Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP-MS
Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP-MS
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DOI：
10.1016/j.jtemb.2006.08.001
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发表时间：
2006-01-01
影响因子：
3.5
通讯作者：
Koester, Helmut D.
中科院分区：
文献类型：
--
作者：
Heitland, Peter;Koester, Helmut D.
对生活在北方德国不莱梅大区域的130名职业非暴露志愿者的血液样本中的微量元素Ag、As、Au、B、Ba、Be、Bi、Cd、Ce、Co、Cs、Cu、Ga、Hf、Hg、In、La、Mn、Mo、Ni、Pb、Pd、Rb、Rh、Ru、Sb、Se、Sr、Te、Th、TI、U、V、W、Y和Zr进行了测定。将血液样品收集在开发用于痕量金属测定的肝素锂monovettes中，并通过电感耦合等离子体质谱法（ICP-MS）和基于八极杆的碰撞/反应池进行分析。为了将样品引入ICP中，用0.1% Triton-X-100和0.5%（V/V）氨溶液将血液样品稀释1/10（V/V）。我们开发的常规方法的方法验证描述了所有37个元素和内部和外部质量保证的结果进行了讨论。所有人类受试者的暴露条件的信息通过基于电子邮件的访谈收集，包括吸烟习惯，海鲜消费和牙齿中的牙科合金类型。给出了人体血液中所有元素浓度的平均值、几何平均值、范围和选定的最大值，这有助于毒理学家和临床化学家计划研究金属暴露及其对健康的影响。(c)2006年Elsevier GmbH。All rights reserved.
The trace elements Ag, As, Au, B, Ba, Be, Bi, Cd, Ce, Co, Cs, Cu, Ga, Hf, Hg, In, La, Mn, Mo, Ni, Pb, Pd, Rb, Rh, Ru, Sb, Se, Sri, Sr, Te, Th, TI, U, V, W, Y and Zr were determined in 130 human blood samples from occupationally non-exposed volunteers living in the greater area of Bremen in northern Germany. The blood samples were collected in lithium heparin monovettes developed for trace metal determination and were analysed by inductively coupled plasma mass spectrometry (ICP-MS) with an octopole-based collision/reaction cell. For sample introduction into the ICP, the blood samples were diluted 1/10 (V/V) with a 0.1% Triton-X-100 and 0.5% (V/V) ammonia solution. The method validation of our developed routine method is described for all 37 elements and results about internal and external quality assurance are discussed. Information on exposure conditions of all human subjects were collected by questionnaire-based interviews, including smoking habits, seafood consumption and the type of dental alloys in the teeth. Mean values, geometric mean values, ranges and selected percentiles of all elemental concentrations in human blood are presented, which helps toxicologists and clinical chemists planning research about exposition to metals and health effects caused by exposition to metals. (c) 2006 Elsevier GmbH. All rights reserved.