Simple Conversion of Enamines to 2H-Azirines and Their Rearrangements under Thermal Conditions
Simple Conversion of Enamines to 2H-Azirines and Their Rearrangements under Thermal Conditions
复制标题
DOI：
10.1021/ol9006663
复制
发表时间：
2009-06-18
期刊：
影响因子：
5.2
通讯作者：
Zhao, Kang
中科院分区：
文献类型：
--
作者：
Li, Xiaoxun;Du, Yunfei;Zhao, Kang
首先发现了多种取代的烯胺衍生物在苯基碘（III）二乙酸酯（PIDA）介导下方便地转化为相应的2 H-氮杂环丙烷。合成的2-芳基-2H-氮杂环丙烷可用于热重排合成吲哚-3-腈或异恶唑。
A variety of substituted enamine derivatives were first found to be conveniently converted to the corresponding 2H-azirines mediated by phenyliodine (III) diacetate (PIDA). The formed 2-aryl-2H-azirines could be applied in the synthesis of indole-3-carbonitriles or isoxazoles via thermal rearrangements.