Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR
复制标题
DOI：
10.1182/blood.2019001212
复制
发表时间：
2019-09-19
期刊：
影响因子：
20.3
通讯作者：
Pidala, Joseph
中科院分区：
文献类型：
--
作者：
Dehn, Jason;Spellman, Stephen;Pidala, Joseph
异基因造血细胞移植涉及考虑供体和受体的特征，以指导选择合适的移植物。充分的高分辨率供受者HLA匹配是最重要的移植与成人无关的捐助者，使用传统的移植物抗宿主病的预防。在脐带血移植中，最佳单位选择需要考虑单位质量、细胞剂量和HLA匹配。在本摘要中，国家骨髓捐献者计划（NMDP）和国际血液和骨髓移植研究中心与NMDP组织相容性咨询小组联合提供了以证据为基础的指南，用于最佳选择无关供体和脐带血单位。
Allogeneic hematopoietic cell transplantation involves consideration of both donor and recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution donor-recipient HLA match is of primary importance in transplantation with adult unrelated donors, using conventional graft-versus-host disease prophylaxis. In cord blood transplantation, optimal unit selection requires consideration of unit quality, cell dose and HLA-match. In this summary, the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow Transplant Research, jointly with the NMDP Histocompatibility Advisory Group, provide evidence-based guidelines for optimal selection of unrelated donors and cord blood units.