Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity.
Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity.
复制标题
耳鸣和暂时性听力损失会导致噪音引起的大脑活动空间重组的差异。
DOI：
10.1007/s00429-018-1635-z
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发表时间：
2018
影响因子：
3.1
通讯作者：
Holt,AvrilGenene
中科院分区：
文献类型：
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作者：
Muca,Antonela;Standafer,Emily;Apawu,AaronK;Ahmad,Farhan;Ghoddoussi,Farhad;Hali,Mirabela;Warila,James;Berkowitz,BruceA;Holt,AvrilGenene
大的噪声经常导致听觉过敏或听力损失（即，增加或降低对声音的敏感性）。这些情况通常伴有耳鸣（耳鸣）和自发神经元活动（SNA）的变化。区分听觉过敏和听力损失对耳鸣神经相关性的贡献的能力尚未实现。为此，我们使用了行为，电生理学和成像工具的组合来研究噪声引起的耳鸣的两种模型（暂时性听力损失或永久性听力损失）。锰（Mn2+）摄取被用作钙通道功能的量度和SNA的指标。锰的摄取在体内进行了研究，锰增强磁共振成像（MEMRI）在关键的听觉大脑区域涉及耳鸣。在声创伤之后，SNA指数MEMRI显示特定脑核内Mn 2+摄取的空间依赖性重排的证据（即，重组）。上级橄榄复合体和耳蜗核Mn 2+摄取的重组依赖于耳鸣状态。然而，重组下丘的Mn 2+摄取依赖于听觉灵敏度。此外，在永久性听力损失后，观察到Mn 2+摄取减少。总的来说，通过结合听力敏感度，耳鸣和SNA的测试，我们的数据提出了区分听觉过敏和听力损失对耳鸣的贡献的可能性。
Loud noise frequently results in hyperacusis or hearing loss (i.e., increased or decreased sensitivity to sound). These conditions are often accompanied by tinnitus (ringing in the ears) and changes in spontaneous neuronal activity (SNA). The ability to differentiate the contributions of hyperacusis and hearing loss to neural correlates of tinnitus has yet to be achieved. Towards this purpose, we used a combination of behavior, electrophysiology, and imaging tools to investigate two models of noise-induced tinnitus (either with temporary hearing loss or with permanent hearing loss). Manganese (Mn2+) uptake was used as a measure of calcium channel function and as an index of SNA. Manganese uptake was examined in vivo with manganese-enhanced magnetic resonance imaging (MEMRI) in key auditory brain regions implicated in tinnitus. Following acoustic trauma, MEMRI, the SNA index, showed evidence of spatially dependent rearrangement of Mn2+uptake within specific brain nuclei (i.e., reorganization). Reorganization of Mn2+uptake in the superior olivary complex and cochlear nucleus was dependent upon tinnitus status. However, reorganization of Mn2+uptake in the inferior colliculus was dependent upon hearing sensitivity. Furthermore, following permanent hearing loss, reduced Mn2+uptake was observed. Overall, by combining testing for hearing sensitivity, tinnitus, and SNA, our data move forward the possibility of discriminating the contributions of hyperacusis and hearing loss to tinnitus.