Environmental reservoirs of pathogenic mycobacteria across the Ethiopian biogeographical landscape.
Environmental reservoirs of pathogenic mycobacteria across the Ethiopian biogeographical landscape.
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DOI：
10.1371/journal.pone.0173811
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Courtenay O
中科院分区：
文献类型：
--
作者：
King HC;Khera-Butler T;James P;Oakley BB;Erenso G;Aseffa A;Knight R;Wellington EM;Courtenay O
分枝杆菌属包含超过一百五十种公认的物种，其中大多数存在于环境中，其中许多对哺乳动物具有致病性。某些环境分枝杆菌物种可能会干扰卡介苗疫苗接种效果和结核菌素测试解释。使用寡分型检查分枝杆菌成员在埃塞俄比亚各地土壤和水环境中多个物理化学和空间梯度上分布的生物地理趋势，确定了致病菌和重要物种的差异分布。在超过 90% 的水样中发现了结核病复合体，而与卡介苗疫苗效率较低相关的分类群是土壤和水分枝杆菌群落的核心。在水中发现了牛分枝杆菌的储存库，每毫升基因组当量高达 7.3×102。海拔、温度、栖息地和植被类型是土壤和水分枝杆菌群落的重要预测因子。这些结果代表了了解暴露于环境分枝杆菌的潜在风险的第一步，这种风险可能会破坏降低疾病发病率的努力。
The Mycobacterium genus comprises over one-hundred-and-fifty recognised species, the majority of which reside in the environment and many of which can be pathogenic to mammals. Some species of environmental mycobacteria may interfere with BCG vaccination efficacy and in tuberculin test interpretation. Examining biogeographic trends in the distribution of members of the mycobacteria across a number of physicochemical and spatial gradients in soil and water environments across Ethiopia using oligotyping identified differential distributions of pathogenic and significant species. The tuberculosis complex was identified in more than 90% of water samples and taxonomic groups implicated in lower BCG vaccine efficiency were core in both soil and water Mycobacterium communities. A reservoir of Mycobacterium bovis was identified in water, with up to 7.3×102 genome equivalents per ml. Elevation, temperature, habitat and vegetation type were important predictors of both soil and water Mycobacterium communities. These results represent the first step in understanding the potential risk of exposure to environmental mycobacteria that may undermine efforts to reduce disease incidence.