Quantitative 3D VUSE pulmonary MRA
Quantitative 3D VUSE pulmonary MRA
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DOI：
10.1016/s0730-725x(98)00177-5
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发表时间：
1999-04-01
影响因子：
2.5
通讯作者：
Halliburton, SS
中科院分区：
文献类型：
--
作者：
Friedli, JL;Paschal, CB;Halliburton, SS
本研究的目的是在正常志愿者中定量评价自由呼吸三维（3D）可变角度均匀信号激发（VUSE）磁共振血管造影（MRA）技术，以证明正常志愿者的呼吸3D VUSE MRA，并研究自由呼吸3D VUSE MRA技术量化肺移植患者的差异血流的能力。对15例正常志愿者的右肺和8例单肺或双肺移植患者的双肺进行了自由呼吸3D VUSE MRA脉冲序列。还对一名志愿者进行了呼气扫描。未使用造影剂。分析正常肺MRA图像观察到的最大分支水平和远端血管与胸膜之间的最小距离。在患者中，用程序计算每个肺中超过阈值信号水平的MRA像素数来确定差异流。这些值仅与放射性核素灌注（Q）扫描结果进行比较。在正常肺图像中观察到的平均分支顺序为5.9 +/-0.7。肺动脉MRA与Q扫描测量的肺动脉血流量差异具有良好的相关性（R-2 = 0.84，p < 0.005）。除了提供正常肺血管的良好可视化外，该技术还被证明可以准确估计无严重肺瘢痕的肺移植患者的差异血流。(C)1999 Elsevier Science Inc.
The purposes of this study were to quantitatively evaluate a free-breathing three-dimensional (3D) variable angle uniform signal excitation (VUSE) magnetic resonance angiography (MRA) technique in normal volunteers, to demonstrate breathold 3D VUSE MRA in a normal volunteer, and to investigate the ability of the free-breathing 3D VUSE MRA technique to quantify differential flow in lung transplant patients. A free-breathing 3D VUSE MRA pulse sequence was run on the right lungs of 15 normal volunteers and both lungs of eight single or double lung transplant patients. A breathold scan was also used on one volunteer. No contrast agents were used. Normal lung MRA images were analyzed for maximum level of branching observed and minimum distance between distal vessels seen and the pleura, In patients, differential flow was determined with a program that counted the number of MRA pixels over a threshold signal level in each lung. These values mere compared to radionuclide perfusion (Q) scan results. Average observed branching order in normal lung images was 5.9 +/- 0.7. Average distance between the most peripheral vessels seen and the pleura was 0.9 cm, Differential blood flow measured by pulmonary MRA was well correlated with that measured by Q scan (R-2 = 0.84, p < 0.005). In addition to providing good visualization of normal pulmonary vessels, this technique was demonstrated to provide accurate estimates of differential blood flow in lung transplant patients free of serious lung scarring. (C) 1999 Elsevier Science Inc.