Cancer incidence in the US radiologic technologists health study, 1983-1998
Cancer incidence in the US radiologic technologists health study, 1983-1998
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DOI：
10.1002/cncr.11444
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发表时间：
2003-06-15
期刊：
影响因子：
6.2
通讯作者：
Linet, MS
中科院分区：
文献类型：
--
作者：
Sigurdson, AJ;Doody, MM;Linet, MS
背景暴露于低剂量辐射的工作人员可以提供有关公众关注的癌症风险的信息。然而，在低剂量的风险特征需要大量的人群，理想情况下应该包括一个大比例的妇女，这两个很少是可用的。在1983-1998年随访的90，305名美国放射技术人员（77%为女性）中，有关癌症发生率的数据来自邮寄问卷和死亡记录。标准化发病率（SIR）是使用来自监测、流行病学和最终结果项目的年龄特异性、性别特异性、种族特异性和日历年特异性癌症发病率计算的。两种性别合并的所有癌症的SIR为1.04（95%置信区间[95% CI]，1.00-1.07; n = 3292名技术人员）。女性技术人员患所有实体瘤的风险增加（SIR = 1.06; 95% CI，1.02-1.10; n = 2168例女性）和乳腺癌（SIR = 1.16; 95% CI，1.09-1.23; n = 970名女性）、黑色素瘤（SIR = 1.66; 95% CI，1.43-1.89; n = 181名女性）和甲状腺癌（SIR = 1.54; 95% CI，1.24-1.83; n = 107名女性）。男性技术人员的实体瘤风险降低（SIR = 0.92; 95% CI，0.85-0.98; n = 755例男性）;然而，黑色素瘤（SIR = 1.39; 95% CI; 1.00-1.79; n = 56例男性）和甲状腺癌（SIR = 2.23; 95% CI，1.29-3.59; n = 17例男性）增加。在两种性别中，颊腔/咽癌的风险降低（SIR = 0.73; 95% CI，0.55-0.90; n 54名技术人员），直肠癌（SIR = 0.62; 95%CI 0.48-0.76; n = 53技术人员）和肺癌（SIR = 0.77，95%CI 0.70-0.85; n = 307技术人员）。乳腺癌风险的增加可能与职业辐射照射有关。观察到的黑色素瘤和甲状腺癌的过度可能至少部分反映了容易获得保健的医务工作者的早期发现。2003年由美国癌症协会出版。
BACKGROUND. Workers exposed to low doses of radiation can provide information regarding cancer risks that are of public concern. However, characterizing risk at low doses requires large populations and ideally should include a large proportion of women, both of which rarely are available.METHODS. Among 90,305 radiologic technologists in the U.S. (77% women) who were followed during 1983-1998, data concerning incident cancer occurrence was obtained from mailed questionnaires and from death records. Standardized incidence ratios (SIRs) were computed using age-specific, gender-specific, race-specific, and calendar year-specific cancer rates from the Surveillance, Epidemiology, and End Results Program.RESULTS. The SIR for all cancers in both genders combined was 1.04 (95% confidence interval [95% CI], 1.00-1.07; n = 3292 technologists). Female technologists had an elevated risk for all solid tumors combined (SIR = 1.06; 95% Cl, 1.02-1.10; n = 2168 women) and for breast cancers (SIR = 1.16; 95% Cl, 1.09-1.23; n = 970 women), melanoma (SIR = 1.66; 95% Cl, 1.43-1.89; n = 181 women), and thyroid cancers (SIR = 1.54; 95% Cl, 1.24-1.83; n = 107 women). Male technologists experienced a decreased risk for solid tumors (SIR = 0.92; 95% CI, 0.85-0.98; n = 755 men); however, melanoma (SIR = 1.39; 95% CI; 1.00-1.79; n = 56 men) and thyroid cancers (SIR = 2.23; 95% CI, 1.29-3.59; n = 17 men) were increased. Among both genders, the risks were decreased for buccal cavity/pharyngeal cancers (SIR = 0.73; 95% CI, 0.55-0.90; n 54 technologists), rectal cancers (SIR = 0.62; 95% Cl 0.48-0.76; n = 53 technologists), and lung cancers (SIR = 0.77, 95% Cl, 0.70-0.85; n = 307 technologists).CONCLUSIONS. The elevated risk for breast cancer may have been related to occupational radiation exposure. The observed excesses of melanoma and thyroid cancers may reflect, at least in part, earlier detection among medical workers with easy access to health care. Published 2003 by the American Cancer Society.