Stem cells and the formation of the myocardium in the vertebrate embryo.
Stem cells and the formation of the myocardium in the vertebrate embryo.
复制标题
脊椎动物胚胎中的干细胞和心肌的形成。
DOI：
10.1002/ar.a.10130
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Eisenberg,CarolA
中科院分区：
文献类型：
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作者：
Eisenberg,LeonardM;Kubalak,StevenW;Eisenberg,CarolA
心血管生物学的一个主要目标是用新产生的心肌组织修复患病或受损的心脏。干细胞为恢复心脏功能提供了替代心肌细胞的潜在来源。然而，人们对能够产生心肌的细胞的性质以及它们形成心脏组织所需的条件知之甚少。可能与解决这些问题有关的信息来源是研究心肌如何从早期脊椎动物胚胎的祖细胞中产生。因此，本综述将研究心脏发育生物学的初始事件，以深入了解可用于产生用于治疗目的的心肌组织的干细胞的身份和特征。Anat Rec Part A 276A：2-12，2004.© 2004 Wiley利斯公司
A major goal in cardiovascular biology is to repair diseased or damaged hearts with newly generated myocardial tissue. Stem cells offer a potential source of replacement myocytes for restoring cardiac function. Yet little is known about the nature of the cells that are able to generate myocardium and the conditions they require to form heart tissue. A source of information that may be pertinent to addressing these issues is the study of how the myocardium arises from progenitor cells in the early vertebrate embryo. Accordingly, this review will examine the initial events of cardiac developmental biology for insights into the identity and characteristics of the stem cells that can be used to generate myocardial tissue for therapeutic purposes. Anat Rec Part A 276A:2–12, 2004. © 2004 Wiley‐Liss, Inc.