The 5q- syndrome.
The 5q- syndrome.
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DOI：
10.1080/10245330410001723824
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发表时间：
2004-08-01
期刊：
影响因子：
--
通讯作者：
Aul, C
中科院分区：
文献类型：
--
作者：
Giagounidis, A A N;Germing, U;Aul, C
5q综合征是一种独特的血液学疾病，具有典型的实验室、形态学、细胞遗传学、分子和预后特征。其定义为骨髓增生异常综合征，骨髓原始细胞计数≥ 5%或增加一个核型异常严重降低中位总生存期。最有前途的治疗方法是新型沙利度胺类似物CC5013，目前正在国际II期研究中进行评估。
The 5q- syndrome is a distinct hematological disorder with typical laboratory, morphological, cytogenetic, molecular, and prognostic features. It is defined as a myelodysplastic syndrome with a medullary blast count or =5% or the addition of one karyotypic anomaly severely reduces median overall survival. The most promising therapeutic approach is the novel thalidomide analogue CC5013 that is currently evaluated in an international phase II study.