CHANGES WITH AGE IN CEREBRAL CAPILLARY MORPHOLOGY
CHANGES WITH AGE IN CEREBRAL CAPILLARY MORPHOLOGY
复制标题
DOI：
10.1016/0197-4580(81)90037-3
复制
发表时间：
1981-01-01
影响因子：
4.2
通讯作者：
GAETANO, PK
中科院分区：
文献类型：
--
作者：
BURNS, EM;KRUCKEBERG, TW;GAETANO, PK
研究了4、10和20岁猴（Macaca nemestrina）和1、14、35、180和800日龄Sprague-Dawley大鼠脑毛细血管形态的年龄相关变化。随着年龄的增长，猴额皮质脑毛细血管壁厚度显著减小，而大鼠无明显变化，猴脑毛细血管基底层厚度显著增加，但在4 ~ 10岁时，猴脑毛细血管基底层厚度显著增加;猴脑毛细血管内皮细胞线粒体含量显著下降，而大鼠脑毛细血管内皮细胞线粒体含量仅在35日龄时达到峰值，与800日龄时相比才显著下降; 5只20岁猴中1只出现异常紧密连接和BL增厚。在大鼠和猴中，随着年龄的增长，脑毛细血管屏障特性受损。
Age related alterations in cerebral capillary morphology were investigated in 4, 10 and 20 yr old monkeys (Macaca nemestrina) and in 1, 14, 35, 180 and 800 day old Sprague-Dawley rats. The following changes were revealed with increasing age: a significant decrease in cerebral capillary wall thickness in frontal cortex in monkeys but not in rats; a significant increase in the thickness of basal lamina (BL) of cerebral capillaries in rats but not in monkeys, but there was a marked increase in this parameter in the monkey between 4 and 10 yr of age; a significant decline in cerebral capillary endothelial mitochondrial content in monkeys whereas a significant decline in this parameter in rats was found only when the peak content at 35 days was contrasted with that at 800 days of age; and, aberrant tight junctions and thickened BL in one of 5 20-yr old monkeys. Impairment of barrier characteristics of cerebral capillaries with increasing age is suggested in both the rat and the monkey.