Clustering of long-term trends in metabolic syndrome variables from childhood to adulthood in blacks and whites - The Bogalusa Heart Study
Clustering of long-term trends in metabolic syndrome variables from childhood to adulthood in blacks and whites - The Bogalusa Heart Study
复制标题
DOI：
10.1093/aje/kwm105
复制
发表时间：
2007-09-01
影响因子：
5
通讯作者：
Berenson, Gerald S.
中科院分区：
文献类型：
--
作者：
Chen, Wei;Srinivasan, Sathanur R.;Berenson, Gerald S.
代谢综合征变量长期变化率的聚类（体重指数，胰岛素抵抗的稳态模型评估，甘油三酯与高密度脂蛋白胆固醇的比率，和平均动脉压）进行纵向评估（1982-2003）在一个队列的389名黑人和631名白人谁检查3-6次都作为儿童（4-17岁）和成年人（18-38岁）平均16年（3，874次观察）。生长曲线下的增量面积被用来衡量儿童时期以来风险变量的长期变化率。四个变量的组内相关性（聚类程度的度量）在儿童期、成年期和增量面积值中具有显著性（p < 0.001），并且成年期高于儿童期。与白人相比，黑人在风险变量的长期变化率方面表现出更高的聚集程度。调整体重指数后，聚类程度降低了约50%。这些结果表明，代谢综合征变量不仅在儿童期和成年期的水平上共存，而且在长期变化率方面也共存。肥胖在代谢综合征的发展中至关重要，需要从儿童时期开始进行预防。
Clustering of long-term rates of change in metabolic syndrome variables (body mass index, homeostasis model assessment of insulin resistance, ratio of triglycerides to high-density lipoprotein cholesterol, and mean arterial pressure) from childhood to adulthood was evaluated longitudinally (1982-2003) in a cohort of 389 Blacks and 631 Whites who were examined 3-6 times both as children (ages 4-17 years) and as adults (ages 18-38 years) over an average of 16 years (3,874 observations). The incremental area under the growth curve was used as a measure of long-term rates of change in risk variables since childhood. Intraclass correlations, a measure of the degree of clustering, among the four variables were significant (p < 0.001) for childhood, adulthood, and incremental area values and were higher in adulthood than in childhood. Blacks showed a higher degree of clustering of long-term rates of change in risk variables than did Whites. Adjustment for body mass index reduced the degree of clustering by approximately 50%. These results show that metabolic syndrome variables coexist in terms not only of their levels in childhood and adulthood but also of long-term rates of change. Obesity is of critical importance in the development of metabolic syndrome, and its prevention beginning in childhood needs to be addressed.