Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques
Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques
复制标题
DOI：
10.1530/joe-12-0459
复制
发表时间：
2013-02-01
影响因子：
4
通讯作者：
Havel, Peter J.
中科院分区：
文献类型：
--
作者：
Cummings, Bethany P.;Bremer, Andrew A.;Havel, Peter J.
地塞米松具有诱导胰岛素抵抗和增加胰岛素分泌的作用。在此，我们研究了地塞米松增加恒河猴胰岛素分泌的作用的潜在贡献者。六只雄性恒河猴每天接受盐水或地塞米松（0.25mg/kg i. m. 7天），治疗间隔3周。在给药期结束时，动物禁食过夜，并在第二天进行喂养研究，在此期间，在餐前和餐后60分钟采集血样，以评估胰岛激素和肠促胰岛素分泌。地塞米松诱导空腹血浆胰岛素、胰高血糖素、瘦素和脂联素浓度显著升高（P
Dexamethasone has well-described effects to induce insulin resistance and increase insulin secretion. Herein, we examined potential contributors to the effect of dexamethasone to increase insulin secretion in rhesus macaques. Six male rhesus macaques received daily injections of either saline or dexamethasone (0.25 mg/kg i.m. for 7 days) in random order with 3 weeks between treatments. At the end of the treatment period, animals were fasted overnight and underwent a feeding study the next day, during which blood samples were taken before and for 60 min after a meal in order to assess islet hormone and incretin secretion. Dexamethasone induced marked increases in fasting plasma insulin, glucagon, leptin, and adiponectin concentrations (P