Lung function, respiratory symptoms, and mortality: Results from the Busselton Health Study
Lung function, respiratory symptoms, and mortality: Results from the Busselton Health Study
复制标题
DOI：
10.1016/s1047-2797(98)00066-0
复制
发表时间：
1999-07-01
影响因子：
5.6
通讯作者：
Musk, AW
中科院分区：
文献类型：
--
作者：
Knuiman, MW;James, AL;Musk, AW
目得：本研究探讨了肺功能[FEV 1预测值百分比]（1秒用力呼气量）]和呼吸道症状在布塞尔顿健康研究中，对2100名男性和2177名女性的队列进行了20-26年的死亡率随访，结果显示：共有840名男性和637名女性在随访期间死亡，考克斯比例风险回归被用来评估危险因素和mortality.RESULTS之间的关系：肺功能是显着和独立的预测死亡率的所有原因，冠心病，癌症和呼吸系统疾病的男性和女性，和死亡率中风的女性。有证据表明，在男性中，与从不吸烟的人相比，目前和以前吸烟的人之间的联系更强。在调整了年龄、吸烟、肺功能、冠心病、血压、高血压治疗、总胆固醇、体重指数和饮酒量等因素后，男性和女性的呼吸困难与总死亡率以及男性的呼吸系统疾病死亡率显著相关，女性的哮喘与呼吸系统疾病死亡率显著相关。肺功能与许多疾病的死亡率相关，与吸烟和呼吸道症状无关。虽然大多数呼吸道症状与吸烟和肺功能有关，但在控制吸烟和肺功能后，只有呼吸困难与非呼吸道原因的死亡率有关。(C)1999 Elsevier Science Inc. All rights reserved.
PURPOSE: This study examines the association between lung function [percentage predicted FEV1 (forced expiratory volume in 1 s)] and respiratory symptoms (asthma, bronchitis, wheeze, dyspnea) and mortality from all causes; coronary heart disease, stroke, cancer, and respiratory disease in a cohort of 2100 men and 2177 women in the Busselton Health Study followed for 20-26 years for mortality.METHODS: A total of 840 men and 637 women died during the follow-up period, and Cox proportional hazards regression was used to assess the relationships between risk factors and mortality.RESULTS: Lung function was significantly and independently predictive of mortality from all causes, coronary heart disease, cancer, and respiratory disease in both men and women, and of mortality from stroke in women. There was evidence that, among men, the association was stronger in current and former smokers as compared to those who never smoked. After adjustment for age, smoking, lung function, coronary heart disease, blood pressure, treatment for hypertension, total cholesterol, body mass index, and alcohol consumption, dyspnea was significantly related to total mortality in men and women and to respiratory disease mortality in men, and asthma was significantly related to respiratory disease mortality in women.CONCLUSIONS: Lung function is associated with mortality from many diseases independent of smoking and respiratory symptoms. Although most respiratory symptoms are associated with smoking and lung function, after controlling for smoking and lung function, only dyspnea is associated with mortality from nonrespiratory causes. (C) 1999 Elsevier Science Inc. All rights reserved.