Sex- and age-related differences in c-fos expression in dog olfactory bulbs
Sex- and age-related differences in c-fos expression in dog olfactory bulbs
复制标题
狗嗅球中 c-fos 表达的性别和年龄相关差异
DOI：
10.1111/azo.12178
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发表时间：
2017
期刊：
影响因子：
1.2
通讯作者：
Guo Dongge
中科院分区：
文献类型：
--
作者：
Wei Qinguo;Zhang Honghai;Ma Shisheng;Guo Dongge
经常报道与性别和年龄相关的认知能力差异。然而，由于生物系统导致的狗嗅觉的性别和年龄相关差异仍然知之甚少。我们通过免疫组织化学方法检查了狗嗅球中的 c-fos 表达。 Thec-fosis主要表达于嗅肾小球层（GL）、二尖瓣细胞层（ML）和颗粒细胞层（GRL）。我们发现，与雄性狗相比，在成年雌性狗的嗅球ML中可以检测到更高密度的c-fos阳性细胞，并且雌性嗅球中的c-fos阳性细胞更加明显。幼年犬嗅球 GL 中 c-fos 表达的性别相关差异也出现。我们还发现，成年犬GRL中c-fos阳性细胞的密度远高于幼犬GRL中的密度。我们的研究结果表明，雌性狗嗅球中的细胞比雄性狗更活跃，并且雌性狗对气味的长期记忆能力可能比雄性狗更强。此外，我们的结果还表明，成年狗对气味的长期记忆能力可能比幼年狗更强，能够处理更复杂的气味信息。
Sex‐ and age‐related differences in cognitive abilities are frequently reported. However, the sex‐ and age‐related differences in dog olfaction due to biological system are still poorly understood. We examinedc‐fosexpression in dog olfactory bulbs by immunohistochemistry approaches. Thec‐fosis mainly expressed in the olfactory glomerular layer (GL), mitral cell layer (ML) and granule cell layer (GRL). We found that a higher density ofc‐fos‐positive cells could be detected in the ML of olfactory bulbs of adult female dogs compared with that in males and thec‐fos‐positive cells in females' olfactory bulbs are more distinct. Sex‐related differences in c‐fosexpression also appeared in the GL of olfactory bulbs in juvenile dogs. We also discovered that the density ofc‐fos‐positive cells in the GRL of adult dogs was much higher than that in the GRL of juvenile dogs. Our results indicate that cells in the olfactory bulbs of female dogs are more active than those in males and female dogs may have much stronger ability for long‐time memory of odours than male dogs. Furthermore, our results also suggest that adult dogs may have much stronger ability for long‐time memory of odours and can deal with more complicated odour information than juvenile dogs.