Selective deficit in no-go performance induced by blockade of prefrontal cortical α2-adrenoceptors in monkeys
Selective deficit in no-go performance induced by blockade of prefrontal cortical α2-adrenoceptors in monkeys
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DOI：
10.1097/01.wnr.0000070831.57864.7b
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发表时间：
2003-05-23
期刊：
影响因子：
1.7
通讯作者：
Li, BM
中科院分区：
文献类型：
--
作者：
Ma, CL;Qi, XL;Li, BM
Two monkeys (Macaca mulatto) were trained to make a go response (go to touch a computer screen) when a red signal (go signal) was presented or a no-go response (inhibit the screen-touching action) when a green signal (no-go signal) was given. The alpha(2)-adrenergic antagonist yohimbine was infused locally, bilaterally and continuously for 8 days into the prefrontal cortex (PFC) by using mini-osmotic pump. The no-go but not go performance was selectively impaired during the 8-day administration of yohimbine: the monkeys showed an inability to inhibit the touching response to the no-go signal, indicating that there was a deficit in the inhibitory ability of the animals. Similar infusion of saline into the same cortical area was without effect. The present study provides behavioral pharmacological evidence that alpha(2)-adrenoceptors in the PFC are involved in the neural mechanisms underlying response inhibition.
