POSSIBLE IMPORTANCE OF MACROPHAGE-DERIVED MEDIATORS IN ACUTE MALARIA
POSSIBLE IMPORTANCE OF MACROPHAGE-DERIVED MEDIATORS IN ACUTE MALARIA
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DOI：
10.1128/iai.32.3.1058-1066.1981
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发表时间：
1981-01-01
影响因子：
3.1
通讯作者：
WOOD, PR
中科院分区：
文献类型：
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作者：
CLARK, IA;VIRELIZIER, JL;WOOD, PR
肿瘤坏死因子，淋巴细胞活化因子和增强水平的I型干扰素被发现在血清样品后2小时小鼠感染疟原虫vinckei亚种。Petteri接受了少量的内毒素静脉注射。这3种介质是在施用牛分枝杆菌BCG或短棒状杆菌后2周小鼠接受内毒素注射时释放的介质。有间接证据表明，这种更广泛的调解人也释放在P.诉ssp。Petteri感染的小鼠注射肠外内毒素。最近的一份报告指出，在疟疾感染的小鼠和儿童的血浆中可检测到内毒素，这意味着这些介质也可能在自然感染的急性期释放。这些巨噬细胞衍生的介质可能在糖皮质激素拮抗作用、骨髓抑制、发热、高丙种球蛋白血症、脾肿大、血清淀粉样蛋白A升高、消耗性凝血病和休克综合征以及伴随疟疾的相关器官损伤中起重要作用。在某些疟疾的危象中，红细胞内寄生虫的死亡，以及随后特异性保护性免疫的发展，也可能依赖于这些介质。
Tumor necrosis factor, lymphocyte-activating factor and enhanced levels of type I interferon were found in serum samples taken 2 h after mice infected with Plasmodium vinckei ssp. petteri received a small i.v. injection of endotoxin. These 3 mediators are among those released when mice receive an endotoxin injection 2 wk after Mycobacterium bovis BCG or Corynebacterium parvum have been administered. There is indirect evidence that this wider range of mediators is also released in P. v. ssp. petteri-infected mice given parenteral endotoxin. A recent report that endotoxin is detectable in the plasma of malaria-infected mice and children implies that these mediators also may be released in the acute phase of the natural infection. These macrophage-derived mediators may be important in the glucocorticoid antagonism, bone marrow depression, fever, hypergammaglobulinemia, splenomegaly, elevation of serum amyloid A, consumptive coagulopathy and shock syndrome with associated organ damage which can accompany malaria. The intraerythrocytic parasite death seen at crisis in some malarias, as well as the subsequent development of specific protective immunity, also may depend on these mediators.