Association Between Serum Midkine Level and Gastric Precancerous Lesion in Patients with Gastritis.
Association Between Serum Midkine Level and Gastric Precancerous Lesion in Patients with Gastritis.
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DOI：
10.5455/medarh.2022.76.368-372
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发表时间：
2022-10
期刊：
影响因子：
--
通讯作者：
Ganie RA
中科院分区：
文献类型：
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作者：
Siregar J;Darmadi D;Ganie RA
胃癌是世界范围内第五大常见恶性肿瘤，也是仅次于肺癌和结直肠癌的第三大癌症相关死亡率。胃癌的发生始于癌前病变。胃癌前病变的及时诊断和处理可以防止疾病的进展。中期因子是一种与多种肿瘤相关的生长因子，被认为是检测胃癌前病变的标志物。本研究旨在探讨胃炎患者血清中期因子水平与胃癌前病变的关系。在哈吉·亚当·马利克综合医院进行了一项横断面研究。受试者通过连续采样获得。入选标准为年龄在18岁或以上，根据胃镜检查和组织病理学结果诊断为胃炎，并愿意配合研究的患者。每位受试者均接受访谈和内镜检查。采用酶联免疫吸附法（ELISA）测定血清中期因子水平。采用卡方检验、受试者工作特征曲线（ROC曲线）和logistic回归检验。共入组160例受试者，29.4%的受试者患有胃癌前病变。血清中期因子水平与胃癌前病变有关。血清中期因子水平的截止点为252 pg/mL，曲线下面积为0.816（p<0.001）。其诊断胃癌前病变的敏感性、特异性和准确性分别为74.5%、71.7%和72.5%。幽门螺杆菌感染、中期因子水平升高、酗酒、胃癌家族史是胃癌前病变的危险因素。血清中期因子水平与胃炎患者胃粘膜癌前病变有关，具有较好的诊断价值。
Gastric cancer is the fifth most common malignancy and the third highest cancer-related mortality worldwide after lung and colorectal cancers. The gastric carcinogenesis is started with precancerous lesion. Prompt diagnosis and management of gastric precancerous lesion may prevent disease progression. Midkine is a growth factor associated with various cancers and proposed as a marker for detecting gastric precancerous lesion. The aim of the study is to determine the association between serum midkine level and gastric precancerous lesion in patients with gastritis. A cross sectional study was conducted at Haji Adam Malik general hospital. Subjects were obtained by consecutive sampling. Inclusion criteria were patients aged 18 years or older, diagnosed with gastritis from gastroscopy and histopathology results, and willing to cooperate in the study. Each subjects underwent interview and endoscopic examination. Serum midkine level was determined using enzyme-linked immunosorbent assay (ELISA) method. Chi square, receiver operating characteristic (ROC) curve, and logistic regression tests were applied. A total of 160 subjects were enrolled with 29.4% had gastric precancerous lesion. Serum midkine level was associated with gastric premalignant lesion. Cut off point for serum midkine level was 252 pg/mL with area under the curve of 0.816 (p<0.001). It’s sensitivity, specificity, and accuracy in diagnosing gastric precancerous lesion were 74.5%, 71.7%, and 72.5%, respectively. Helicobacter pylori infection, high serum midkine level, heavy alcohol drinker, and family history of gastric cancer were risk factors for gastric precancerous lesion. Serum midkine level is associated with gastric premalignant lesion in patients with gastritis and has good diagnostic values.