Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura
Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura
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DOI：
10.1016/s0022-510x(03)00124-2
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发表时间：
2003-09-15
影响因子：
4.4
通讯作者：
Montagna, P
中科院分区：
文献类型：
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作者：
Mochi, M;Cevoli, S;Montagna, P
我们通过分析两个多态性标记物（外显子 10 中的 G142A 转变和外显子 IS 中的三基因 (TA)n 重复），对 360 名偏头痛患者、220 名无先兆偏头痛 (MO) 和 140 名有先兆偏头痛 (MA) 以及 200 名对照者的染色体 19p 13.2 上的 LDL 受体基因 (LDLR) 进行了遗传关联研究。 (TA)n 多态性的等位基因分布在无先兆偏头痛 (MO) 和对照以及有先兆偏头痛 (MA) 之间存在显着差异。我们通过这种多态性或与 (TA)n 连锁不平衡的另一种多态性表明研究人群中可能存在 MO 倾向。 (C) 2003 Elsevier Science B.V. 保留所有权利。
We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p 13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon IS. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n. (C) 2003 Elsevier Science B.V. All rights reserved.