A genetic study of immunoglobulin E and atopic disease based on families ascertained through asthmatic children.
A genetic study of immunoglobulin E and atopic disease based on families ascertained through asthmatic children.
复制标题
基于通过哮喘儿童确定的家庭进行的免疫球蛋白 E 和特应性疾病的遗传学研究。
DOI：
10.1159/000153908
复制
发表时间：
1990
期刊：
影响因子：
1.8
通讯作者：
Rao,DC
中科院分区：
文献类型：
--
作者：
Parks,T;Felix,K;Rice,T;Subbarao,PV;Marimuthu,KM;Rao,DC
为探讨血清免疫球蛋白E（IgE）水平与过敏性疾病的遗传方式，收集了42个哮喘患儿家系的血清IgE水平和过敏性疾病资料。尽管平均IgE水平升高（平均637 U/ml），但该人群中特应性疾病的患病率惊人地低。当用复合分离分析法对数据进行分析时，没有检测到主基因座。此外，尽管血清IgE水平与特应性疾病易感性之间的相关性约为0.4，但多基因遗传率出乎意料地小。鉴于这组不寻常的发现，推测该人群中的寄生虫感染（根据寄生虫病的明确结果）导致血清IgE水平升高和过敏性疾病患病率降低，可能掩盖了血清IgE水平和特应性疾病的各种遗传成分。
In order to investigate the modes of inheritance of serum immunoglobulin E (IgE) levels and atopic disease, serum IgE levels and data on allergic disease were obtained from 42 families ascertained through asthmatic children visiting an allergy clinic. Although the mean IgE levels were elevated (mean 637 U/ml), the prevalence of atopic disease in this population was surprisingly low. When the data were analyzed using complex segregation analysis, no major locus could be detected. Moreover, the polygenic heritability was unexpectedly small even though the correlation between serum IgE levels and the liability to atopic disease was around 0.4. Given this unusual set of findings, it is postulated that parasitic infections in this population have (in accordance with well-established results of parasitic disease) caused both elevated levels of serum IgE and a decreased prevalence of allergic disease with the possible masking of the various genetic components of serum IgE levels and atopic disease.