METABOLISM OF ZINGERONE, A PUNGENT PRINCIPLE OF GINGER
METABOLISM OF ZINGERONE, A PUNGENT PRINCIPLE OF GINGER
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DOI：
10.3109/00498257609151654
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发表时间：
1976-01-01
期刊：
影响因子：
1.8
通讯作者：
SOLHEIM, E
中科院分区：
文献类型：
--
作者：
MONGE, P;SCHELINE, R;SOLHEIM, E
研究了生姜的辛辣成分4-（4-羟基-3-甲氧基苯基）丁-2-酮（姜酮）在大鼠体内的代谢。姜酮经口或腹腔给药（100 mg/kg）后，24 h内大多数代谢产物经尿排泄，主要为葡糖苷酸和/或硫酸盐结合物。虽然姜酮本身约占剂量的50-55%，但也发生了相应的甲醇（11-13%）的减少。侧链氧化发生在所有3个可用位点，3位氧化主要产生C6-C2代谢产物。约占剂量的95-97%。发生了明显的胆汁排泄（12小时内40%）。胆汁研究和使用盲肠微生物进行的体外研究表明，尿液中发现的几种O-脱甲基代谢物是细菌来源的。
The metabolism of 4-(4-hydroxy-3-methoxyphenyl)butan-2-one (zingerone), a pungent principle of ginger [from Zingiber officinale], was investigated in rats. Oral or i.p. dosage (100 mg/kg) of zingerone resulted in the urinary excretion of most metabolites within 24 h, mainly as glucuronide and/or sulfate conjugates. While zingerone itself accounted for roughly 50-55% of the dose, reduction to the corresponding carbinol (11-13%) also occurred. Side chain oxidation took place at all 3 available sites and oxidation at the 3-position, giving rise to C6-C2 metabolites, predominated. About 95-97% of the dose was accounted for. Appreciable (40% in 12 h) biliary excretion occurred. Biliary studies and studies in vitro using cecal micro-organisms indicated that several O-demethylated metabolites found in the urine are of bacterial origin.