Facile synthesis of unnatural β-germyl-α-amino amides via Pd(ii)-catalyzed primary and secondary C(sp3)-H bond germylation.
Facile synthesis of unnatural β-germyl-α-amino amides via Pd(ii)-catalyzed primary and secondary C(sp3)-H bond germylation.
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DOI：
10.1039/c8cc08098d
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发表时间：
2018-12
影响因子：
4.9
通讯作者：
Zheng-Xin Zhou;Weihao Rao;Ming‐Hua Zeng;Yue‐Jin Liu
中科院分区：
文献类型：
--
作者：
Zheng-Xin Zhou;Weihao Rao;Ming‐Hua Zeng;Yue‐Jin Liu
本文报道了Pd（Ⅱ）催化的α-AA衍生物在双齿助剂辅助下的C（sp ~ 3）-H直接甲锗化反应，合成β-甲锗基-α-氨基酰胺。该方法对脂肪族酰胺的伯、仲C-H键具有很好的通用性。机理研究表明，一个关键的五元钯中间体可能在这一过程中发挥了关键作用。
Pd(ii)-Catalyzed direct C(sp3)-H germylation of α-AA derivatives with the assistance of a bidentate auxiliary for the efficient synthesis of β-germyl-α-amino amides is reported. This protocol features good generality for primary and secondary C-H bonds of aliphatic amides. Mechanistic studies show that a crucial five-membered palladacycle intermediate may play a key role in this process.