Cytoglobin:: A novel globin type ubiquitously expressed in vertebrate tissues
Cytoglobin:: A novel globin type ubiquitously expressed in vertebrate tissues
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DOI：
10.1093/oxfordjournals.molbev.a004096
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发表时间：
2002-04-01
影响因子：
10.7
通讯作者：
Hankeln, T
中科院分区：
文献类型：
--
作者：
Burmester, T;Ebner, B;Hankeln, T
脊椎动物具有多种呼吸球蛋白，其在结构、功能和组织分布方面不同。到目前为止，已经描述了三种类型的球蛋白：血红蛋白促进血液中氧气的运输，肌红蛋白用于肌肉中氧气的运输和储存。而脑红蛋白在神经细胞中的功能尚未确定。在这里，我们报告的第四种和新类型的珠蛋白在小鼠，人和斑马鱼的鉴定，它是在显然所有类型的人类组织中表达，因此被称为细胞珠蛋白（CYGB）。小鼠和人类CYGB包含190个氨基酸，斑马鱼CYGB。174个氨基酸。人类CYGB基因位于染色体17 q25上。哺乳动物基因显示出独特的外显子-内含子模式，具有额外的外显子，导致蛋白质的C-末端延伸，这在鱼CYGB中不存在。系统发育分析表明，CYGB与脊椎动物肌红蛋白有共同的祖先。这表明脊椎动物肌红蛋白实际上是一种特化的细胞内球蛋白，其进化是为了适应肌肉细胞的特殊需要。
Vertebrates possess multiple respiratory globins that differ in terms of structure, function, and tissue distribution. Three types of globins have been described so far: hemoglobin facilitates the transport of oxygen in the blood, myoglobin serves oxygen transport and storage in the muscle. and neuroglobin has a yet unidentified function in nerve cells. Here we report the identification of a fourth and novel type of globin in mouse, man, and zebrafish, It is expressed in apparently all types of human tissue and therefore has been called cytoglobin (CYGB). Mouse and human CYGBs comprise 190 amino acids, the zebrafish CYGB. 174 amino acids. The human CYGB gene is located on chromosome 17q25. The mammalian genes display a unique exon-intron pattern with an additional exon resulting in a C-terminal extension of the protein, which is absent in the fish CYGB. Phylogenetic analyses Suggest that the CYGBs had a common ancestor with vertebrate myoglobins. This indicates that the vertebrate myoglobins ire in fact a specialized intracellular globin that evolved in adaptation to the special needs of muscle cells.