Designing ideal conduits for peripheral nerve repair.
Designing ideal conduits for peripheral nerve repair.
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DOI：
10.3171/foc.2009.26.2.e5
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发表时间：
2009-02
影响因子：
4.1
通讯作者：
Spinner RJ
中科院分区：
文献类型：
--
作者：
de Ruiter GC;Malessy MJ;Yaszemski MJ;Windebank AJ;Spinner RJ
神经管、导管或导管是自体神经移植修复的一种有前途的替代方法。第一个可生物降解的空单腔或中空神经管目前可用于临床使用，并且主要用于修复神经缺损< 3 cm的小直径神经。这些神经管由不同的生物材料使用各种制造技术制成。因此，这些管的物理性质也不同。此外，正在研究对常见中空神经管的几种修饰（例如，添加施万细胞、生长因子和内部框架），这些修饰可能会增加可以桥接的差距。这种化学、物理和生物因素的结合使得神经导管的设计成为一个复杂的过程，需要生物工程师、神经科学家和周围神经外科医生的密切合作。在这篇文章中，作者讨论了周围神经修复的理想神经导管的设计过程中所涉及的不同步骤。
Nerve tubes, guides, or conduits are a promising alternative for autologous nerve graft repair. The first biodegradable empty single lumen or hollow nerve tubes are currently available for clinical use and are being used mostly in the repair of small-diameter nerves with nerve defects of < 3 cm. These nerve tubes are made of different biomaterials using various fabrication techniques. As a result these tubes also differ in physical properties. In addition, several modifications to the common hollow nerve tube (for example, the addition of Schwann cells, growth factors, and internal frameworks) are being investigated that may increase the gap that can be bridged. This combination of chemical, physical, and biological factors has made the design of a nerve conduit into a complex process that demands close collaboration of bioengineers, neuroscientists, and peripheral nerve surgeons. In this article the authors discuss the different steps that are involved in the process of the design of an ideal nerve conduit for peripheral nerve repair.