SUBSTANCE P-CONTAINING NEURONS IN THE MESOPONTINE TEGMENTUM ARE SEVERELY AFFECTED IN PARKINSONS-DISEASE
SUBSTANCE P-CONTAINING NEURONS IN THE MESOPONTINE TEGMENTUM ARE SEVERELY AFFECTED IN PARKINSONS-DISEASE
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DOI：
10.1093/brain/114.5.2253
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发表时间：
1991-10-01
期刊：
影响因子：
14.5
通讯作者：
BLESSING, WW
中科院分区：
文献类型：
--
作者：
GAI, WP;HALLIDAY, GM;BLESSING, WW
本文对6例帕金森病患者和5例正常对照者的中脑脑桥被盖连续切片进行了P物质免疫反应（SP+）神经元的定量分析。在帕金森病脑的被盖中，许多SP+神经元含有肿胀、扭曲的神经元突起以及路易体。有显着减少的SP+神经元的总数在脚桥被盖核（损失43%），在背侧被盖核（损失28%），在口桥网状核（损失41%）和中缝正中核（损失76%）。尤其是大的SP+（> 20 μ m）神经元受到影响。在我们的对照组中，我们没有记录死亡年龄和这些被盖核中SP+神经元的数量之间或死亡年龄和蓝斑色素神经元的数量之间的显着关系。相反，在帕金森病患者中，死亡年龄与SP+和色素神经元数量之间存在强烈的负相关关系。我们的研究结果表明，帕金森病和其他与衰老相关的过程中发起的病理生理机制之间的相互作用。由于被盖SP+神经元受到帕金森病的主要病理过程的影响，严重的儿茶酚胺合成神经元受到影响，帕金森病的发病机制和治疗策略的理论将需要考虑到这些SP+神经元的参与。
Substance P immunoreactive (SP+) neurons were analysed quantitatively in serial sections of the mesopontine tegmentum in 6 patients with idiopathic Parkinson's disease and 5 age-matched normal controls. In the tegmentum of the Parkinson's disease brains many SP+ neurons contained swollen, twisted neuronal processes as well as Lewy bodies. There were significant reductions in the total number of SP+ neurons in the pedunculopontine tegmental nucleus (loss 43%), in the laterodorsal tegmental nucleus (loss 28%), in the oral pontine reticular nucleus (loss 41%) and in the median raphe nucleus (loss 76%). It was the large SP+ (> 20-mu-m) neurons that were particularly affected. In our control group we did not document a significant relationship between age at death and number of SP+ neurons in these tegmental nuclei or between age at death and number of pigmented neurons in the locus coeruleus. In contrast, in patients with Parkinson's disease, there was a strong inverse relationship between age at death and numbers of SP+ and pigmented neurons. Our findings suggest an interaction between the pathophysiological mechanisms initiated by Parkinson's disease and other processes related to ageing. Since tegmental SP+ neurons are affected by the primary pathological processes underlying Parkinson's disease as severely as catecholamine-synthesizing neurons are affected, theories of pathogenesis and therapeutic strategies in Parkinson's disease will need to take into account the involvement of these SP+ neurons.