High Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with Symptomatic Internal Carotid Artery Stenosis
High Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with Symptomatic Internal Carotid Artery Stenosis
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DOI：
10.1016/j.jstrokecerebrovasdis.2018.09.001
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发表时间：
2019-01-01
影响因子：
2.5
通讯作者：
Raffort, Juliette
中科院分区：
文献类型：
--
作者：
Massiot, Nicolas;Lareyre, Fabien;Raffort, Juliette
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）已被确定为几种心血管疾病的预测因素，但其在颈内动脉（ICA）狭窄患者中的意义仍知之甚少。本研究的目的是确定颈内动脉狭窄行颈动脉内膜切除术患者术前NLR和PLR的临床意义。材料和方法：回顾性纳入连续接受颈动脉内膜切除术治疗ICA狭窄的患者（n = 270）。根据术前NLR和PLR的四分位数值将患者分为2组，共4组：Ia组（NLR < 1.5）、IIa组（1.50 < NLR < 2.07）、IIIa组（2.07 < NLR < 2.95）、IVa组（NLR bb0 2.95）、Ib组（PLR < 86.6）、IIb组（86.6 < PLR < 111.7）、IIIb组（111.7 < PLR < 148.3）、IVb组（PLR bb1 148.3）。比较两组患者的临床特点和术后30天的预后。结果：术后30天有1例死亡（0.4%），总卒中死亡率为1.5%。IVa组出现症状性ICA狭窄的患者比例显著高于Ia、IIa、IIIa组（分别为64.2%、33.8%、44.8%、45.6%,P = 0.005）， IVb组高于Ib、IIb、IIIb组（59.7%、47.1%、35.8%、45.6%,P = 0.051）。两组术后30天全因并发症发生率无显著差异。结论：术前NLR和PLR高与症状性ICA狭窄显著相关。需要进一步的研究来确定它们作为颈动脉内膜切除术患者术后预后的预测因素。
Introduction: The neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have been identified as predictive factors in several cardiovascular diseases but their significance in patients with internal carotid artery (ICA) stenosis is still poorly known. The aim of this study was to determine the clinical significance of the preoperative NLR and PLR in patients with ICA stenosis undergoing carotid endarterectomy. Material and Methods: Consecutive patients who underwent carotid endarterectomy for ICA stenosis were retrospectively included (n = 270). The population was divided into 2 series of 4 groups based on the quartile values of the preoperative NLR and PLR: group Ia (NLR < 1.5), IIa (1.50 < NLR < 2.07), IIIa (2.07 < NLR < 2.95), IVa (NLR>2.95), and group Ib (PLR < 86.6), IIb (86.6 < PLR < 111.7), IIIb (111.7 < PLR < 148.3), IVb (PLR > 148.3). Clinical characteristics and 30day postoperative outcomes were compared among the groups. Results: One death (.4%) was reported during the 30-day postoperative period and the overall stroke and death rate was 1.5%. The proportion of patients with symptomatic ICA stenosis were significantly higher in group IVa compared to groups Ia, IIa, IIIa (64.2% vs 33.8%, 44.8% and 45.6%, respectively, P = .005), and higher in group IVb compared to groups Ib, IIb, IIIb (59.7% vs 47.1%, 35.8%, 45.6%, P = .051). No significant difference on 30-day postoperative all-cause complications was observed among the groups. Conclusions: A high preoperative NLR and PLR is significantly associated with symptomatic ICA stenosis. Further studies are required to determine their interest as predictors of postoperative outcomes in patients undergoing carotid endarterectomy.