Is Obesity Associated With a Decline in Intelligence Quotient During the First Half of the Life Course?
Is Obesity Associated With a Decline in Intelligence Quotient During the First Half of the Life Course?
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DOI：
10.1093/aje/kwt135
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发表时间：
2013-11-01
影响因子：
5
通讯作者：
Moffitt, Terrie E.
中科院分区：
文献类型：
--
作者：
Belsky, Daniel W.;Caspi, Avshalom;Moffitt, Terrie E.
横断面研究发现，肥胖与青少年和成年期的智力低下和神经影像学异常有关。有些人将这些关联解释为肥胖会导致人在生命的前半期智力下降。我们分析了一项前瞻性纵向研究的数据，以测试从童年到中年，肥胖是否与智力下降有关。我们使用的数据来自正在进行的达尼丁多学科健康与发展研究，这是一项对新西兰1,037名儿童进行的人群代表性出生队列研究，这些儿童从出生（1972 - 1973）到40岁进行前瞻性随访，保留率为95留存率。在儿童期和成年期测量智商（IQ）。在出生时和随后的12次亲自评估时进行人体测量。正如预期的那样，肥胖的队列成员成年后的智商得分较低。然而，肥胖的队列成员没有表现出智商的过度下降。相反，这些队列成员从童年起就有较低的智商分数。当我们考虑到儿童出生体重和生命最初几年的生长以及儿童期发病的肥胖时，这种模式保持一致。在后来发展为肥胖的儿童中，早在3岁时就存在较低的智商分数。我们没有观察到肥胖导致智商下降的证据，即使在表现出代谢综合征和/或全身炎症升高的肥胖个体中也是如此。
Cross-sectional studies have found that obesity is associated with low intellectual ability and neuroimaging abnormalities in adolescence and adulthood. Some have interpreted these associations to suggest that obesity causes intellectual decline in the first half of the life course. We analyzed data from a prospective longitudinal study to test whether becoming obese was associated with intellectual decline from childhood to midlife. We used data from the ongoing Dunedin Multidisciplinary Health and Development Study, a population-representative birth cohort study of 1,037 children in New Zealand who were followed prospectively from birth (19721973) through their fourth decade of life with a 95 retention rate. Intelligence quotient (IQ) was measured in childhood and adulthood. Anthropometric measurements were taken at birth and at 12 subsequent in-person assessments. As expected, cohort members who became obese had lower adulthood IQ scores. However, obese cohort members exhibited no excess decline in IQ. Instead, these cohort members had lower IQ scores since childhood. This pattern remained consistent when we accounted for childrens birth weights and growth during the first years of life, as well as for childhood-onset obesity. Lower IQ scores among children who later developed obesity were present as early as 3 years of age. We observed no evidence that obesity contributed to a decline in IQ, even among obese individuals who displayed evidence of the metabolic syndrome and/or elevated systemic inflammation.