Design and Synthesis of N1,N8-Diacetylspermidine Analogues having a Linker with Desired Functional Groups
Design and Synthesis of N1,N8-Diacetylspermidine Analogues having a Linker with Desired Functional Groups
复制标题
具有带有所需官能团的连接体的 N1,N8-二乙酰亚精胺类似物的设计和合成
DOI：
10.1039/c8ob02900h
复制
发表时间：
2018
影响因子：
3.2
通讯作者：
Mitsuhiro Arisawa.
中科院分区：
文献类型：
--
作者：
Reiya Ohta;Akihiro Oguro;Kazuhiro Nishimura;Kenichi Murai;Hiromichi Fujioka;Mitsuhiro Arisawa.
报道了通过理论计算设计的亚甲基骨架上含有所需官能团的新型N1，N8-二乙酰亚精胺(DiAcSpd)类似物的合成。我们还实现了以固相树脂为载体的DiAcSpd的制备，这有可能用于通过指数富集法(SELEX)进化配体。
The synthesis of new N1,N8-diacetylspermidine (DiAcSpd) analogues having a linker with desired functional groups in the methylene skeleton, which have been designed by theoretical calculations, is described. We have also achieved the preparation of DiAcSpd supported on solid-phase resins, which have the potential to be used for the evolution of ligands by exponential enrichment (SELEX).