Global HDO uptake in human glioma xenografts is related to the perfused capillary distribution
Global HDO uptake in human glioma xenografts is related to the perfused capillary distribution
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人胶质瘤异种移植物中的整体 HDO 摄取与灌注毛细血管分布有关
DOI：
--
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发表时间：
1999
影响因子：
3.3
通讯作者：
A. Heerschap
中科院分区：
文献类型：
--
作者：
B. van der Sanden;H. 't Zandt;L. Hoofd;R. D. de Graaf;K. Nicolay;P. Rijken;A. J. van der Kogel;A. Heerschap
本研究的目的是评估人体胶质瘤移植裸鼠体内整体氘标记水（HDO）摄取率与扩散几何形状之间可能存在的关系。通过结合定量1H - MR扩散成像和两种不同灌注血管结构肿瘤系的毛细血管间距离形态计量学分析，估计HDO在整个血管外肿瘤体积中的扩散时间。HDO吸收量采用2H‐磁共振波谱法独立测量。将HDO摄取曲线的时间常数（τ）与最大HDO扩散时间（tdifmax）进行比较。均匀灌注毛细血管分布的肿瘤表现为单指数HDO摄取。tdifmax与HDO摄取曲线的τ值相当：tdifmax在74 - 368秒之间变化，τ值范围为115-370秒。非均匀灌注的肿瘤具有双指数的HDO摄取，tdifmax介于快吸收期和慢吸收期的τ值之间。这些结果表明，人类胶质瘤异种移植物的HDO摄取与灌注毛细血管分布有关。在二维（2D）模型实验中证实，HDO吸收率确实取决于灌注的毛细血管分布。在这些具有扩散限制HDO摄取的模型中，HDO摄取曲线可以通过二维HDO扩散模拟得到的曲线来近似。中华医学杂志，1999。©1999 Wiley‐Liss, Inc。
The aim of this study is to evaluate the existence of a possible relationship between global deuterium‐labeled water (HDO) uptake rates and the diffusion geometry of human glioma xenografts in nude mice. HDO diffusion times in the whole extravascular tumor volume were estimated by combining quantitative 1H‐MR diffusion imaging and morphometric analysis of intercapillary distances in two tumor lines with a different perfused vascular architecture. HDO uptake was measured independently using 2H‐magnetic resonance spectroscopy. Time constants of HDO‐uptake curves (τ) were compared to estimations of maximum HDO diffusion times (tdifmax). Tumors with a homogeneously perfused capillary distribution showed a mono‐exponential HDO uptake. The tdifmax was comparable to τ values of HDO uptake curves: tdifmax varied between 74 and 368 sec and the range of τ values was 115–370 sec. Heterogeneously perfused tumors had a bi‐exponential HDO uptake with tdifmax in between the τ values of the fast and slow uptake phase. These findings indicate that the global HDO uptake is related to the perfused capillary distribution in human glioma xenografts. That HDO uptake rates indeed can depend on the perfused capillary distribution was substantiated in experiments with two‐dimensional (2D) models. In these models with a diffusion‐limited HDO uptake, HDO uptake curves could be approximated by curves derived from 2D HDO diffusion simulations. Magn Reson Med 42:479–489, 1999. © 1999 Wiley‐Liss, Inc.
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影响因子：
11.2
作者：
Y. Boucher;L. T. Baxter;R. Jain
通讯作者：
Y. Boucher;L. T. Baxter;R. Jain
影响因子：
11.2
作者：
J. R. Less;T. Skalak;E. Sevick;R. Jain
通讯作者：
J. R. Less;T. Skalak;E. Sevick;R. Jain
影响因子：
11.2
作者：
Fan Yuan;H. A. Salehi;Y. Boucher;U. Vasthare;R. Tuma;R. Jain
通讯作者：
Fan Yuan;H. A. Salehi;Y. Boucher;U. Vasthare;R. Tuma;R. Jain
DOI：
--
发表时间：
1988-10
期刊：
The American journal of pathology
影响因子：
--
作者：
H. Dvorak;J. Nagy;J. Dvorak;A. Dvorak
通讯作者：
H. Dvorak;J. Nagy;J. Dvorak;A. Dvorak
小鼠肿瘤血流 D2O 清除率测量中示踪剂分布的氘核磁共振成像。
影响因子：
11.2
作者：
LarcombeMcDouall,JB;Evelhoch,JL
通讯作者：
Evelhoch,JL