Simulation of continuous solid phase synthesis: synthesis of methionine enkephalin and its analogs.
Simulation of continuous solid phase synthesis: synthesis of methionine enkephalin and its analogs.
复制标题
连续固相合成模拟：甲硫氨酸脑啡肽及其类似物的合成。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
J. Eichler
中科院分区：
文献类型：
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作者：
M. Lebl;J. Eichler
可通过机械装置从一个合成室转移到另一个合成室的连续固相合成方法，即在连续载体上执行的合成，允许在载体的不同区域上同时执行多个合成步骤。该方法在甲硫氨酸脑啡肽及其类似物的合成中得到验证。以合理的产率获得的产品得到了充分的表征。讨论了连续固相合成器的可能布置和用途。
The method of continuous solid phase synthesis, i.e., synthesis performed on a continual carrier, transferable from one synthetic compartment to another by means of a mechanical device, allows one to perform multiple synthetic steps simultaneously on different regions of the carrier. This procedure was tested on the synthesis of methionine enkephalin and its analogs. Products, obtained in reasonable yields, were fully characterized. Possible arrangements and the use of continuous solid phase synthesizers are discussed.
DOI：
10.1073/pnas.82.15.5131
发表时间：
1985-01-01
影响因子：
11.1
作者：
HOUGHTEN, RA
通讯作者：
HOUGHTEN, RA