Reduced nitric oxide in amniotic fluid of patients with Chorioamnionitis
Reduced nitric oxide in amniotic fluid of patients with Chorioamnionitis
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DOI：
10.1159/000089053
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发表时间：
2006-01-01
影响因子：
2.2
通讯作者：
Togari, H
中科院分区：
文献类型：
--
作者：
Daoud, GA;Suzuki, Y;Togari, H
目的：一氧化氮（NO）和细胞因子的水平进行了评估，从严重绒毛膜炎（CAM）和适当的控制患者的羊水。研究方法：从12例CAM患者（妊娠17-24周）和89例接受诊断性羊膜穿刺术（妊娠16-18周）的患者中获得羊水。测定羊水中NO、白细胞介素-6（IL-6）和白细胞弹性蛋白酶（LE）的浓度并进行比较。结果：CAM患者血清NO、IL-6、LE水平均高于正常孕妇。此外，在CAM组中，NO与LE之间呈负相关。结论：这些结果表明，在严重的CAM中，NO的作用可能会减少，不仅由于作用的阻断，而且由于降解，尽管产量增加。版权所有（c）2006 S. Karger AG，巴塞尔。
Objective: Levels of nitric oxide (NO) and cytokines were assessed in amniotic fluid obtained from patients with severe chorioamnionitis (CAM) and appropriate controls. Methods: Amniotic fluid was obtained from 12 patients with CAM (17-24 weeks of gestation) and 89 patients undergoing diagnostic amniocentesis (16-18 weeks of gestation). The concentrations of NO, interleukin-6 (IL-6), and leukocyte elastase (LE) in amniotic fluid were then measured and compared. Results: The concentrations of NO, IL-6, and LE were all higher in CAM cases than in normal pregnant women. Furthermore, an inverse correlation between NO and LE was suggested in the CAM group. Conclusions: These results indicate that in severe CAM, the action of NO might be reduced, not only due to blockage of action but also by degradation, despite increased production. Copyright (c) 2006 S. Karger AG, Basel.